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Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample

dc.contributor.authorVan Rensburg E.J.
dc.contributor.authorEngelbrecht S.
dc.contributor.authorVan Heerden W.F.P.
dc.contributor.authorRaubennheimer E.J.
dc.contributor.authorSchoub B.D.
dc.date.accessioned2011-05-15T16:15:33Z
dc.date.available2011-05-15T16:15:33Z
dc.date.issued1996
dc.identifier.citationAnticancer Research
dc.identifier.citation16
dc.identifier.citation2
dc.identifier.issn02507005
dc.identifier.urihttp://hdl.handle.net/10019.1/13387
dc.description.abstractBackground. The incidence of oral squamous cell carcinoma (OSCC) is on the increase in developing countries. Materials and Methods. Formalin fixed paraffin embedded blocks of OSCCs from a Black South African population sample of peri-urban and rural origin were selected as follows: Group 1-57 OSCCs with a mean age of 59 years; Group 2 - 43 OSCCs all cases younger than 40 years; Group 3 - 46 OSCCs with blocks containing only tumour tissue without any normal epithelium and Group 4, a control group of 38 non-neoplastic epithelial lesions. Type specific primers were used in a standard PCR to amplify a segment of the E6 region of HPV 6, 11, 16 and 18. Results. HPV 11 and 16 DNA were found in one sample each from groups 1 and 2 respectively. Conclusion. HPV is not an etiologic factor in the development of OSCC in the population studied.
dc.subjectformaldehyde
dc.subjectparaffin
dc.subjectvirus dna
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdeveloping country
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmale
dc.subjectmouth carcinoma
dc.subjectnegro
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectsquamous cell carcinoma
dc.subjectwart virus
dc.subjectAdult
dc.subjectAfrican Americans
dc.subjectAfrican Continental Ancestry Group
dc.subjectBase Sequence
dc.subjectCarcinoma, Squamous Cell
dc.subjectDNA, Viral
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMolecular Sequence Data
dc.subjectMouth Neoplasms
dc.subjectPapillomaviridae
dc.subjectSouth Africa
dc.titleHuman papillomavirus DNA in oral squamous cell carcinomas from an African population sample
dc.typeArticle
dc.description.versionArticle


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