Warthin's tumour is not an Epstein-Barr virus related disease
Date
1999
Authors
Van Heerden W.F.P.
Kraft K.
Hemmer J.
Swart T.J.P.
Van Heerden M.B.
Van Rensburg E.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: The histogenesis of Warthin's tumour (WT) is controversial. A possible role for Epstein-Barr virus (EBV) has been suggested. Materials and Methods: Twenty formaldehyde-fixed, paraffin-embedded blocks of WT from the parotid gland were examined for the presence of EBV. In situ hybridisation was performed using EBV encoded small nuclear RNAs (EBER1/2) probes labelled with fluorescein isothiocyanate. An EBV-positive P3HR-1 cell line processed to paraffin wax was used as a positive control and a brain section as negative control. Results: EBER1/2 could not be found in the neoplastic epithelial cells in any of the tumours nor in the adjacent normal parotid tissues. Individual positive lymphocytes were present in 7 tumours. Conclusions: These results indicated that EBV is not involved in the pathogenesis of WT.
Description
Keywords
fluorescein isothiocyanate, paraffin, small nuclear RNA, adult, aged, article, cell line, clinical article, controlled study, epithelium cell, Epstein Barr virus, female, human, human tissue, in situ hybridization, lymphocyte, male, parotid gland, pathogenesis, priority journal, Warthin tumor, Adenolymphoma, Herpesvirus 4, Human, Humans, In Situ Hybridization, Male, Middle Aged, RNA, Viral
Citation
Anticancer Research
19
4 B
19
4 B