Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches
Date
2021-02
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis
(TB), causing high mortality or disability. Clinical management of the disease is
challenging due to limitations of the existing diagnostic approaches. Our knowledge
on the immunology and pathogenesis of the disease is currently limited. More research
is urgently needed to enhance our understanding of the immunopathogenesis
of the disease and guide us toward the identification of targets that may be useful
for vaccines or host-directed therapeutics. In this review, we summarize the current
knowledge about the immunology and pathogenesis of TBM and summarize the literature
on existing and new, especially biomarker-based, approaches that may be useful in
the management of TBM. We identify research gaps and provide directions for research
which may lead to the development of new tools for the control of the disease in the
near future.
Description
CITATION: Manyelo CM, Solomons RS, Walzl G,
Chegou NN. 2021. Tuberculous meningitis:
pathogenesis, immune responses, diagnostic
challenges, and the potential of biomarker-based
approaches. J Clin Microbiol 59:e01771-20.
doi.10.1128/JCM.01771-20.
The original publication is available at: asm.org
The original publication is available at: asm.org
Keywords
Meninges -- Tuberculosis, Central nervous system -- Diseases, Biochemical markers, Immune response, Meninges -- Pathogenesis
Citation
Manyelo CM, Solomons RS, Walzl G, Chegou NN. 2021. Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based
approaches. J Clin Microbiol 59:e01771-20.
doi.10.1128/JCM.01771-20.