A critical appraisal of the clinical pharmacokinetics of isoniazid

Abstract

The work presented in this thesis has contributed to the clarification of a number of issues related to the clinical pharmacokinetics of isoniazid and hydrozine in juvenile and adult patients of both sexes subject to potentially deleterious environmental factors: acute tuberculous disease; nutritional deprivation; simultaneous ingestion of rifampicin, pyrazinamide and ethionamide, each of which is potentially toxic in its own right. The advances are embodied in the developments listed here below. ...