Effect of HIV infection status and Anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants

Madhi S.A. ; Adrian P. ; Cotton M.F. ; McIntyre J.A. ; Jean-Philippe P. ; Meadows S. ; Nachman S. ; Kayhty H. ; Klugman K.P. ; Violari A. (2010)


Serotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4+ cell percentages ≥25% who initiated immediate antiretroviral treatment (the HIV+/ART+ group) or whose antiretroviral treatment was deferred until clinically or immunologically indicated (the HIV+/ART+ group). Immune responses were also evaluated in HIV-noninfected infants born to HIV-seronegative (M+/I+) or HIV-positive mothers (M+/I+). Antibody concentrations were similar between HIV+/ART+ and HIV+/ART+ infants. However, antibody concentrations were lowerin M+/I+ infants than in M+/I+ infants. Nevertheless, M+/I+ infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART+ infants. © 2010 by the Infectious Diseases Society of America.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/12668
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