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Genetic susceptibility to tuberculosis in Africans : a genome-wide scan

dc.contributor.authorBellamy, Richarden_ZA
dc.contributor.authorBeyers, Nuldaen_ZA
dc.contributor.authorMcAdam, Keith P. W. J.en_ZA
dc.contributor.authorRuwende, Cyrilen_ZA
dc.contributor.authorGie, Roberten_ZA
dc.contributor.authorSamaai, Priscillaen_ZA
dc.contributor.authorBester, Daniteen_ZA
dc.contributor.authorMeyer, Mandyen_ZA
dc.contributor.authorCorrah, Tumanien_ZA
dc.contributor.authorCollin, Matthewen_ZA
dc.contributor.authorCamidge, D. Rossen_ZA
dc.contributor.authorWilkinson, Daviden_ZA
dc.contributor.authorHoal-Van Helden, Eileenen_ZA
dc.contributor.authorWhittle, Hilton C.en_ZA
dc.contributor.authorAmos, Williamen_ZA
dc.contributor.authorVan Helden, Paulen_ZA
dc.contributor.authorHill, Adrian V. S.en_ZA
dc.date.accessioned2011-05-15T16:02:20Z
dc.date.available2011-05-15T16:02:20Z
dc.date.issued2000
dc.identifier.citationBellamy, R., et al, 2000. Genetic susceptibility to tuberculosis in Africans : a genome-wide scan. Proceedings of the National Academy of Sciences, 97(14):8005–8009, doi:10.1073/pnas.140201897
dc.identifier.issn1091-6490 (online)
dc.identifier.issn0027-8424 (print)
dc.identifier.otherdoi:10.1073/pnas.140201897
dc.identifier.urihttp://hdl.handle.net/10019.1/12423
dc.descriptionCITATION: Bellamy, R., et al, 2000. Genetic susceptibility to tuberculosis in Africans : a genome-wide scan. Proceedings of the National Academy of Sciences, 97(14):8005–8009, doi:10.1073/pnas.140201897.
dc.descriptionThe original publication is available at https://www.pnas.org
dc.description.abstractHuman genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to search for regions of the human genome containing tuberculosis-susceptibility genes. This approach uses sibpair families that contain two full siblings who have both been affected by clinical tuberculosis. For any chromosomal region containing a major tuberculosis-susceptibility gene, affected sibpairs inherit the same parental alleles more often than expected by chance. In the first round of the screen, 299 highly informative genetic markers, spanning the entire human genome, were typed in 92 sibpairs from The Gambia and South Africa. Seven chromosomal regions that showed provisional evidence of coinheritance with clinical tuberculosis were identified. To identify whether any of these regions contained a potential tuberculosis-susceptibility gene, 22 markers from these regions were genotyped in a second set of 81 sibpairs from the same countries. Markers on chromosomes 15q and Xq showed suggestive evidence of linkage (lod = 2.00 and 1.77, respectively) to tuberculosis. The potential identification of susceptibility loci on both chromosomes 15q and Xq was supported by an independent analysis designated common ancestry using microsatellite mapping. These results indicate that genome-wide linkage analysis can contribute to the mapping and identification of major genes for multifactorial infectious diseases of humans. An X chromosome susceptibility gene may contribute to the excess of males with tuberculosis observed in many different populations.
dc.description.urihttps://www.pnas.org/content/97/14/8005
dc.format.extent5 pages
dc.publisherNational Academy of Sciences
dc.subjectMycobacterium tuberculosis
dc.subjectTuberculosis
dc.titleGenetic susceptibility to tuberculosis in Africans : a genome-wide scanen_ZA
dc.typeArticle
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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