5-HT2A: Its role in frontally mediated executive function and related psychopathology
Date
2007
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Abstract
Serotonin (5-HT)2A receptors are widely distributed, with high levels in the frontal cortex, where postsynaptic activation may increase activity in pyramidal glutamatergic neurons and mediate various executive functions. More specifically, reciprocal cortical-raphe pathways may allow the ventral prefrontal cortex to inhibit stress-induced neural activity in the brainstem when stressors are perceived as controllable. However, early adversity and negative attitudes may be associated with higher frontal 5-HT2A receptor levels and greater risk for stress-induced psychopathology, and certain 5-HT2A gene variants have been associated with increased risk for impulsive behavior. Conversely, many antidepressants result in decreased levels of 5-HT2A receptor levels, and blockade of 5-HT2A receptors has proven useful in the treatment of a number of psychiatric disorders.
Description
Keywords
antidepressant agent, glucocorticoid, mianserin, mirtazapine, nefazodone, serotonin 2A receptor, serotonin 2B receptor, serotonin 2C receptor, serotonin uptake inhibitor, trazodone, allele, article, binding site, case report, clinical feature, diagnostic and statistical manual of mental disorders, drug mechanism, drug withdrawal, gene expression, genetic variability, genotype, human, impulsiveness, liver toxicity, male, mental disease, pessimism, priority journal, recurrent disease, risk factor, sexual dysfunction, signal transduction, single nucleotide polymorphism, upregulation, attitude, cognitive defect, frontal lobe, major depression, mental stress, metabolism, pathophysiology, positron emission tomography, psychological aspect, Attitude, Cognition Disorders, Depressive Disorder, Major, Frontal Lobe, Humans, Male, Positron-Emission Tomography, Receptor, Serotonin, 5-HT2A, Serotonin Uptake Inhibitors, Stress, Psychological, Trazodone
Citation
CNS Spectrums
12
7
12
7