A comparative analysis of kinetic models of erythrocyte glycolysis
Date
2008
Authors
du Preez F.B.
Conradie R.
Penkler G.P.
Holm K.
van Dooren F.L.J.
Snoep J.L.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.
Description
Keywords
2,3 diphosphoglyceric acid, adenosine diphosphate, adenosine triphosphate, glutathione, reduced nicotinamide adenine dinucleotide phosphate, biological production, catabolism, comparative study, cytology, glucose, homeostasis, peptide, reaction rate, article, comparative study, concentration (parameters), enzyme activity, erythrocyte, glycolysis, homeostasis, human, kinetics, metabolic regulation, nuclear magnetic resonance, priority journal, quantitative analysis, Adenosine Triphosphate, Erythrocytes, Glutathione, Glycolysis, Humans, Models, Cardiovascular
Citation
Journal of Theoretical Biology
252
3
252
3