Antibiogram profiles and efficacy of antibiotic regimens of bacterial isolates from chronic osteomyelitis of the appendicular skeleton: A developing-world perspective

Ferreira, N. ; Reddy, K. ; Venter, R. G. ; Centner, C. M. ; Laubscher, M. (2021-06-30)

CITATION: Ferreira, N. et al. 2021. Antibiogram profiles and efficacy of antibiotic regimens of bacterial isolates from chronic osteomyelitis of the appendicular skeleton : a developing-world perspective. South African Medical Journal, 111(7):642-648, doi:10.7196/SAMJ.2021.v111i7.15516.

The original publication is available at http://www.samj.org.za

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ENGLISH ABSTRACT: Chronic osteomyelitis is notoriously difficult to eradicate, and high treatment failure rates have been reported in the literature.[1,2] Although no evidence-based treatment guidelines exist for the management of chronic osteomyelitis, the ideal treatment strategy can be outlined as judicious resection of all necrotic tissue, dead-space management, and neovascularisation of the debridement site followed by soft-tissue and bony reconstruction as required.[3-7] Antibiotic therapy is empirically initiated as an adjunct to surgical management, and then continued as prolonged culture-specific (targeted) therapy.[3]In the absence of non-invasive sampling methods to ascertain the microbiological profile of osteomyelitis, the choice of empirical antibiotic therapy to initiate is often aimed at the most probable infecting organism, in conjunction with current international reports.[8] As the organism and antibiotic susceptibility profiles conceivably differ between geographical regions, empirical antibiotic strategies should ideally be based on local microbiological antibiograms. There are limited data available on the local pathogen profiles and antibiograms in developing countries, including South Africa (SA).

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