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Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape

dc.contributor.authorDe Wit E.
dc.contributor.authorDelport W.
dc.contributor.authorRugamika C.E.
dc.contributor.authorMeintjes A.
dc.contributor.authorMoller M.
dc.contributor.authorVan Helden P.D.
dc.contributor.authorSeoighe C.
dc.contributor.authorHoal E.G.
dc.date.accessioned2011-05-15T15:59:11Z
dc.date.available2011-05-15T15:59:11Z
dc.date.issued2010
dc.identifier.citationHuman Genetics
dc.identifier.citation128
dc.identifier.citation2
dc.identifier.issn3406717
dc.identifier.other10.1007/s00439-010-0836-1
dc.identifier.urihttp://hdl.handle.net/10019.1/11041
dc.description.abstractAdmixed populations present unique opportunities to discover the genetic factors underlying many multifactorial diseases. The geographical position and complex history of South Africa has led to the establishment of the unique admixed population known as the South African Coloured. Not much is known about the genetic make-up of this population, and the historical record is patchy. We genotyped 959 individuals from the Western Cape area, self-identified as belonging to this population, using the Affymetrix 500k genotyping platform. This resulted in nearly 75,000 autosomal SNPs that could be compared with populations represented in the International HapMap Project and the Human Genome Diversity Project. Analysis by means of both the admixture and linkage models in STRUCTURE revealed that the major ancestral components of this population are predominantly Khoesan (32-43%), Bantu-speaking Africans (20-36%), European (21-28%) and a smaller Asian contribution (9-11%), depending on the model used. This is consistent with historical data. While of great historical and genealogical interest, this information is also essential for future admixture mapping of disease genes in this population. © 2010 Springer-Verlag.
dc.subjectAfrica
dc.subjectarticle
dc.subjectAsian
dc.subjectcontrolled study
dc.subjectEurope
dc.subjectgenetic identification
dc.subjectgenetic variability
dc.subjectgenetics
dc.subjectgenome analysis
dc.subjectgenotype
dc.subjecthuman
dc.subjecthuman genome
dc.subjectmajor clinical study
dc.subjectpopulation genetics
dc.subjectpriority journal
dc.subjectrace difference
dc.subjectsingle nucleotide polymorphism
dc.subjectSouth Africa
dc.subjectCaucasian
dc.subjectethnic and racial groups
dc.subjectethnic group
dc.subjectgenome
dc.subjectgeography
dc.subjectmale
dc.subjectNegro
dc.subjectresearch
dc.subjectAfrican Continental Ancestry Group
dc.subjectAsian Continental Ancestry Group
dc.subjectEthnic Groups
dc.subjectEuropean Continental Ancestry Group
dc.subjectGenome
dc.subjectGenotype
dc.subjectGeography
dc.subjectHumans
dc.subjectMale
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPopulation Groups
dc.subjectResearch
dc.subjectSouth Africa
dc.titleGenome-wide analysis of the structure of the South African Coloured Population in the Western Cape
dc.typeArticle
dc.description.versionArticle


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