Xylocaine® 10% pump spray as topical anaesthetic for venepuncture pain

Van Straten, A. ; Murray, A. A. ; Levin, A. I. (2018)

CITATION: Van Straten, A., Murray, A. A. & Levin, A. I. 2018. Xylocaine® 10% pump spray as topical anaesthetic for venepuncture pain. Southern African Journal of Anaesthesia and Analgesia, 24(3):75-78, doi:10.1080/22201181.2018.1450200.

The original publication is available at https://www.tandfonline.com


Background: Cutaneous analgesia for venepuncture pain can be achieved using various topically applied local anaesthetic formulations. Xylocaine® 10% Pump Spray containing lignocaine hydrochloride and 95% ethanol is exclusively recommended for mucosal anaesthesia. However, this formulation is readily able to penetrate skin. This study investigated whether topical pre-treatment with Xylocaine® 10% Pump Spray could facilitate analgesia for venepuncture. Methods: A single-centre, prospective, randomised, double-blind placebo-controlled trial was conducted. One hundred patients were enrolled. The control and intervention groups had 0.5 ml saline and 0.5 ml Xylocaine® applied for 20 min to preselected venepuncture sites. Pain associated with an 18-gauge cannula venepuncture was rated on an 11-point Numerical Rating Scale. A two-point or 30% reduction in pain would be deemed clinically significant. Results: Pain scores were lower (p = 0.001) in the Xylocaine® (median 2; 95% CI 2–3) than the saline (median 4; 95% CI 3–5) group. Moderate-to-severe pain occurred in fewer Xylocaine® (18%) than saline (42%) treated patients (relative risk 0.43, CI 0.22 to 0.48; NNT = 5). Conclusion: Topical Xylocaine® 10% Pump Spray pre-treatment provided a time-effective method of reducing venepuncture-associated pain.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/107539
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