Browsing Research Articles (Clinical Pharmacology) by Title
Now showing items 1-20 of 79
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The 12-month period prevalence and cardiac manifestations of HIV in patients with acute coronary syndrome at a tertiary hospital in Cape Town, South Africa : a retrospective cross-sectional study
(BMC (part of Springer Nature), 2021)Background: HIV-positive patients are increasingly being affected by non-communicable diseases such as coronary artery disease (CAD). Data from high-income countries (HICs) indicate that HIV-positive patients have different ... -
A 3-year survey of acute poisoning exposures in infants reported in telephone calls made to the Tygerberg Poison Information Centre, South Africa
(Health & Medical Publishing Group, 2016-03)ENGLISH ABSTRACT: Background. Infants undergo rapid development changes and are particularly vulnerable to toxic chemicals. Identifying and evaluating the toxic risks that exist in this age group could be very valuable ... -
Aberrant apoptotic response of colorectal cancer cells to novel nucleoside analogues
(Public Library of Science, 2015)Despite the increased understanding of colorectal cancer and the introduction of targeted drug therapy, the metastatic phase of the disease remains refractory to treatment. Since the deregulation of normal apoptosis ... -
Abnormal serum lipoprotein levels as a risk factor for the development of human lenticular opacities
(Clinics Cardiv Publishing, 2003-04)Aim: To determine whether an association exists between the different plasma lipoprotein constituents and the prevalence of lenticular opacities in dyslipidaemic subjects. Methods: Adult patients (n = 115) of both genders ... -
Accelerating clinical evaluation of repurposed combination therapies for COVID-19
(American Society of Tropical Medicine and Hygiene, 2020-08-21)As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions, there is a pressing need to accelerate treatment evaluations. Among options for accelerated ... -
Aminoglycoside monitoring: Perspective on current trends in the Western Cape
(Health and Medical Publishing Group (HMPG), 2005)[No abstract available] -
Angio-oedema associated with colistin
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: A 50-year-old woman known to have type 1 diabetes mellitus presented with a rare case of angio-oedema associated with colistin use. The angio-oedema was temporally associated with the use and discontinuation ... -
Another look at erythromycin
(Health & Medical Publishing Group, 1978-04)ENGLISH ABSTRACT: The erythromycins are broadly reviewed from a clinical viewpoint. The antimicrobial spectrum, clinical indications, pharmacokinetics and toxicity are dealt with. The usefulness of erythromycin for ... -
Application of Caco-2 cell line in herb-drug interaction studies : current approaches and challenges
(Canadian Society for Pharmaceutical Sciences, 2014-01)The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical ... -
Artemisia Spp. derivatives for COVID-19 treatment : anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials
(American Society of Tropical Medicine and Hygiene, 2020)The world is currently facing a novel COVID-19 pandemic caused by SARS-CoV-2 that, as of July 12, 2020, has caused a reported 12,322,395 cases and 556,335 deaths. To date, only two treatments, remdesivir and dexamethasone, ... -
Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa
(Frontiers Media, 2017-12-18)Background: Health-related quality of life (HRQOL) and adherence to treatment are two often inter-related concepts that have implications for patient management and care. Tuberculosis (TB) and its treatment present a major ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Berg adder (Bitis atropos) : an unusual case of acute poisoning
(Health and Medical Publishing Group, 2017)A 5-year-old boy presented to hospital with mild local cytotoxic and severe neurotoxic symptoms. The neurotoxic symptoms included ptosis, fixed dilated pupils and flaccid paralysis with respiratory failure. Mild hyponatraemia ... -
Biomarkers of HIV-associated cancer
(Libertas Academica, 2014)Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ... -
Black and brown widow spider bites in South Africa. A series of 45 cases
(Health & Medical Publishing Group, 1993-6)ENGLISH ABSTRACT: Cases of black widow (Latrodectus indistinctus) and brown widow (L. geometricus) spider bites referred to the Tygerberg Pharmacology and Toxicology Consultation Centre from the summer of 1987/88 to the ... -
‘Building on shaky ground’—challenges to and solutions for primary care guideline implementation in four provinces in South Africa : a qualitative study
(BMJ Publishing, 2020-05)Objectives Clinical guidelines support evidence-informed quality patient care. Our study explored perspectives of South African subnational health managers regarding barriers to and enablers for implementation for all ... -
Chemical incompatibility of parenteral drug admixtures
(Health & Medical Publishing Group, 1974)Incompatibilty of parenteral drug admixtures is a subject with such wide ramifications that the problem of correlating all the factors will in future probably only be controlled by computer techniques. In the meantime, ... -
Chloroquine and hydroxychloroquine for the prevention or treatment of Novel Coronavirus Disease (COVID-19) in Africa : caution for inappropriate off-label use in healthcare settings
(American Society of Tropical Medicine and Hygiene, 2020)ENGLISH ABSTRACT: The novel severe acute respiratory syndrome-coronavirus-2 pandemic has spread to Africa, where nearly all countries have reported laboratory-confirmed cases of novel coronavirus disease (COVID-19). ... -
Clinical trials of disease stages in COVID 19 : complicated and often misinterpreted
(Elsevier, 2020-08-20)As of July 28, 2020, 1840 clinical trials were registered globally, with 1001 clinical trials recruiting patients for COVID-19 management.1 Despite this large number, only 30 trials have been published as peer-reviewed or ... -
Comparative study of different brands of stavudine capsules for the off-label 'opened capsule' dosing method recommended for HIV-infected infants and children in resource-limited settings
(Health and Medical Publishing Group, 2009)Introduction. If a caregiver does not have access to a refrigerator, the South African National Department of Health advises that stavudine adult capsule formulations be employed using the off-label 'opened capsule' dosing ...
