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Now showing items 1-14 of 14
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Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa
(Frontiers Media, 2017-12-18)Background: Health-related quality of life (HRQOL) and adherence to treatment are two often inter-related concepts that have implications for patient management and care. Tuberculosis (TB) and its treatment present a major ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Biomarkers of HIV-associated cancer
(Libertas Academica, 2014)Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ... -
Comparative study of different brands of stavudine capsules for the off-label 'opened capsule' dosing method recommended for HIV-infected infants and children in resource-limited settings
(Health and Medical Publishing Group, 2009)Introduction. If a caregiver does not have access to a refrigerator, the South African National Department of Health advises that stavudine adult capsule formulations be employed using the off-label 'opened capsule' dosing ... -
Education and training for medicines development, regulation, and clinical research in emerging countries
(Frontiers Media, 2015)The aim of this satellite workshop held at the 17th World Congress of Basic and Clinical Pharmacology (WCP2014) was to discuss the needs, optimal methods and practical approaches for extending education and teaching of ... -
Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa
(BioMed Central, 2016-03-11)Introduction: Tuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective ... -
Health-related quality of life in South African patients with pulmonary tuberculosis
(Public Library of Science, 2017)Background: The evaluation of patient-reported health-related quality of life (HRQOL) in pulmonary tuberculosis (TB) contributes to a comprehensive understanding of the burden associated with this disease. The aim of ... -
How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis – designing a prospective observational study in South Africa
(Frontiers Media, 2016)Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adherence to tuberculosis ... -
In vitro assessment of the interaction potential of ocimum basilicum (L.) extracts on CYP2B6, 3A4, and rifampicin metabolism
(Frontiers Media, 2020-04-30)ENGLISH ABSTRACT: Ocimum basilicum L. or basilicum is a common culinary herb, used as a traditional medicine for various medical conditions including HIV/AIDS and tuberculosis, in Africa. The objective of this study was ... -
Inhibitory interactions of Aspalathus linearis (Rooibos) extracts and compounds, aspalathin and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs
(MDPI, 2016-11-12)Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of ... -
An overview of the evidence and mechanisms of herb-drug interactions
(Frontiers, 2012-04-30)Despite the lack of sufficient information on the safety of herbal products, their use as alternative and/or complementary medicine is globally popular. There is also an increasing interest in medicinal herbs as precursor ... -
The potential of Hypoxis hemerocallidea for herb-drug interaction
(Informa Healthcare, 2013)Context: Aqueous decoction of Hypoxis hemerocallidea Fisch. & C.A. Mey. (Hypoxidaceae) (Hypoxis) is widely consumed in Southern Africa by people living with HIV/AIDS, some of whom are on ARV and other medications. Objective: ... -
Snake bites, spider bites and scorpion stings
(Health and Medical Publications Group (HMPG), 2012-10)Exposure of humans to natural toxins occurs via snake bites, spider bites and scorpion stings, or by plant or mushroom poisonings. According to the WHO (http://www.who.int/neglected_diseases/ diseases/snakebites/en/), ... -
A Validated stable HPLC method for the simultaneous determination of rifampicin and 25-O-desacetyl rifampicin – evaluation of in vitro metabolism
(Akademiai Kiado, 2017)A simple, efficient, and stable high-performance liquid chromatography (HPLC) separation method for a combination of rifampicin (RIF), its major metabolite 25-O-desacetyl rifampicin (25ODESRIF), and neostigmine (NEO) was ...
