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Contemporary best practice in the management of malignant pleural effusion

dc.contributor.authorKoegelenberg, Coenraad F. N.en_ZA
dc.contributor.authorShaw, Jane A.en_ZA
dc.contributor.authorIrusen, Elvis M.en_ZA
dc.contributor.authorLee, Y. C. Garyen_ZA
dc.date.accessioned2019-11-13T09:37:45Z
dc.date.available2019-11-13T09:37:45Z
dc.date.issued2018
dc.identifier.citationKoegelenberg, C. F. N., et al. 2018. Contemporary best practice in the management of malignant pleural effusion. Therapeutic Advances in Respiratory Disease, 12:1-13, doi:10.1177/ 1753466618785098
dc.identifier.issn1753-4666 (online)
dc.identifier.issn1753-4658 (print)
dc.identifier.otherdoi:10.1177/1753466618785098
dc.identifier.urihttp://hdl.handle.net/10019.1/106836
dc.descriptionCITATION: Koegelenberg, C. F. N., et al. 2018. Contemporary best practice in the management of malignant pleural effusion. Therapeutic Advances in Respiratory Disease, 12:1-13, doi:10.1177/ 1753466618785098.
dc.descriptionThe original publication is available at https://journals.sagepub.com
dc.description.abstractENGLISH ABSTRACT: Malignant pleural effusion (MPE) affects more than 1 million people globally. There is a dearth of evidence on the therapeutic approach to MPE, and not surprisingly a high degree of variability in the management thereof. We aimed to provide practicing clinicians with an overview of the current evidence on the management of MPE, preferentially focusing on studies that report patient-related outcomes rather than pleurodesis alone, and to provide guidance on how to approach individual cases. A pleural intervention for MPE will perforce be palliative in nature. A therapeutic thoracentesis provides immediate relief for most. It can be repeated, especially in patients with a slow rate of recurrence and a short anticipated survival. Definitive interventions, individualized according the patient’s wishes, performance status, prognosis and other considerations (including the ability of the lung to expand) should be offered to the remainder of patients. Chemical pleurodesis (achieved via intercostal drain or pleuroscopy) and indwelling pleural catheter (IPC) have equal impact on patient-based outcomes, although patients treated with IPC spend less time in hospital and have less need for repeat pleural drainage interventions. Talc slurry via IPC is an attractive recently validated option for patients who do not have a nonexpandable lung.en_ZA
dc.description.urihttps://journals.sagepub.com/doi/10.1177/1753466618785098
dc.format.extent13 pagesen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherSAGE Publicationsen_ZA
dc.subjectPleurodesisen_ZA
dc.subjectCathetersen_ZA
dc.subjectLung canceren_ZA
dc.titleContemporary best practice in the management of malignant pleural effusionen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyrighten_ZA


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