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Larger subcortical gray matter structures and smaller corpora callosa at age 5 years in HIV infected children on early ART

Randall, Steven R.; Warton, Christopher M. R.; Holmes, Martha J.; Cotton, Mark F.; Laughton, Barbara; Van der Kouwe, Andre J. W.; Meintjes, Ernesta M. (Frontiers Media, 2017)

Sub-Saharan Africa is home to 90% of HIV infected (HIV+) children. Since the advent of antiretroviral therapy (ART), HIV/AIDS has transitioned to a chronic condition where central nervous system (CNS) damage may be ongoing. ...

Universal children’s day : let’s improve current interventions to reduce vertical transmission of HIV now

Cotton, Mark F.; Rabie, Helena (International AIDS society, 2014-11-20)

By 2013, there was a 40% decline in new paediatric infections compared to 2009. Prevention of mother to child transmission (PMTCT) of HIV continues to reduce the frequency of HIV in infants through wider and earlier ...

No evidence of HIV replication in children on antiretroviral therapy

Van Zyl, Gert U.; Katusiime, Mary Grace; Wiegand, Ann; McManus, William R.; Bale, Michael J.; Halvas, Elias K.; Luke, Brian; Boltz, Valerie F.; Spindler, Jonathan; Laughton, Barbara; Engelbrecht, Susan; Coffin, John M.; Cotton, Mark F.; Shao, Wei; Mellors, John W.; Kearney, Mary F. (American Society for Clinical Investigation, 2017-04)

ENGLISH ABSTRACT: It remains controversial whether current antiretroviral therapy (ART) fully suppresses the cycles of HIV replication and viral evolution in vivo. If replication persists in sanctuary sites such as the ...

Effects of postnatal interventions for the reduction of vertical HIV transmission on infant growth and non-HIV infections : a systematic review

Zunza, Moleen; Mercer, Gareth D.; Thabane, Lehana; Esser, Monika; Cotton, Mark F. (BioMed Central, 2013-12-20)

Introduction: Guidelines in resource-poor settings have progressively included interventions to reduce postnatal HIV transmission through breast milk. In addition to HIV-free survival, infant growth and non-HIV infections ...

Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life

Laughton, Barbara; Naidoo, Shalena; Dobbels, Els; Boivin, Michael J.; Janse van Rensburg, Anita; Glashoff, Richard H.; Van Zyl, Gert U.; Kruger, Mariana; Cotton, Mark F. (AOSIS, 2019-10-03)

Background: Antiretroviral therapy (ART) started between 7 and 12 weeks of age improves neurodevelopmental outcomes in HIV-infected (HIV+) infants, but the impact of even earlier initiation is not yet described. Objectives: ...

Antiretroviral therapy for the management of HIV in children

Frigati, L.; Cotton, Mark F.; Rabie, H. (Health & Medical Publishing Group, 2014-12)

Since 2004, when antiretroviral therapy (ART) was first available to children through the National Department of Health, there has been significant progress in preventing and treating paediatric HIV. Large cohort studies ...

Antiretroviral therapy in children - increased benefit from increased complexity

Cotton, Mark F. (Health & Medical Publishing Group, 2000-10)

Antiretroviral therapy (ART) started as monotherapy with significant short-term gains. With the advent of newer drugs management has become more complex, but with significant gains in quality and quantity of life. The ...

Five year neurodevelopment outcomes of perinatally HIV-infected children on early limited or deferred continuous antiretroviral therapy

Laughton, Barbara; Cornell, Morna; Kidd, Martin; Springer, Priscilla Estelle; Dobbels, Els; Van Rensburg, Anita Janse; Otwombe, Kennedy; Babiker, Abdel; Gibb, Diana M.; Violari, Avy; Kruger, Mariana; Cotton, Mark F. (Wiley Open Access, 2018)

Introduction: Early antiretroviral therapy (ART) has improved neurodevelopmental outcomes of HIV-infected (HIV-positive) children; however, little is known about the longer term outcomes in infants commencing early ART ...

Thymic output and CD4 T-cell reconstitution in HIV-infected children on early and interrupted antiretroviral treatment : evidence from the children with HIV early antiretroviral therapy trial

Lewis, Joanna; Payne, Helen; Walker, A. Sarah; Otwombe, Kennedy; Gibb, Diana M.; Babiker, Abdel G.; Panchia, Ravindre; Cotton, Mark F.; Violari, Avy; Klein, Nigel; Callard, Robin E. (Frontiers, 2017-09)

Objectives: Early treatment of HIV-infected children and adults is important for optimal immune reconstitution. Infants’ immune systems are more plastic and dynamic than older children’s or adults’, and deserve particular ...