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Variation in HIV prevalence and the population-level effects of antiretroviral therapy in reducing tuberculosis incidence in South Africa

Sloot, R.; Maarman, G. J.; Osman, M.; Marx, F. M. (Health & Medical Publishing Group, 2018)

The current year (2018) marks the 10th year after the tuberculosis (TB) epidemic in South Africa (SA) reached a historic peak of 848 incident TB cases per 100 000 population in 2008.[1,2] TB incidence has since decreased ...

Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life

Laughton, Barbara; Naidoo, Shalena; Dobbels, Els; Boivin, Michael J.; Janse van Rensburg, Anita; Glashoff, Richard H.; Van Zyl, Gert U.; Kruger, Mariana; Cotton, Mark F. (AOSIS, 2019-10-03)

Background: Antiretroviral therapy (ART) started between 7 and 12 weeks of age improves neurodevelopmental outcomes in HIV-infected (HIV+) infants, but the impact of even earlier initiation is not yet described. Objectives: ...

Antiretroviral therapy in children - increased benefit from increased complexity

Cotton, Mark F. (Health & Medical Publishing Group, 2000-10)

Antiretroviral therapy (ART) started as monotherapy with significant short-term gains. With the advent of newer drugs management has become more complex, but with significant gains in quality and quantity of life. The ...

Thymic output and CD4 T-cell reconstitution in HIV-infected children on early and interrupted antiretroviral treatment : evidence from the children with HIV early antiretroviral therapy trial

Lewis, Joanna; Payne, Helen; Walker, A. Sarah; Otwombe, Kennedy; Gibb, Diana M.; Babiker, Abdel G.; Panchia, Ravindre; Cotton, Mark F.; Violari, Avy; Klein, Nigel; Callard, Robin E. (Frontiers, 2017-09)

Objectives: Early treatment of HIV-infected children and adults is important for optimal immune reconstitution. Infants’ immune systems are more plastic and dynamic than older children’s or adults’, and deserve particular ...