Now showing items 1-5 of 5
The PREVENT study to evaluate the effectiveness and acceptability of a community-based intervention to prevent childhood tuberculosis in Lesotho : study protocol for a cluster randomized controlled trial
(BioMed Central, 2017-11-21)
Background: Effective, evidence-based interventions to prevent childhood tuberculosis (TB) in high TB/HIV-burden, resource-limited settings are urgently needed. There is limited implementation of evidence-based contact ...
Low vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is associated with tuberculosis and death in HIV-infected and -exposed infants
(Public Library of Science, 2016)
Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. ...
Child contact management in high tuberculosis burden countries : a mixed-methods systematic review
(Public Library of Science, 2017-03-08)
ENGLISH Abstract: Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. Considering the World Health Organization recommendation to implement child contact management (CCM) for TB, we conducted a ...
The wonder years : what can primary school children teach us about immunity to mycobacterium tuberculosis?
(Frontiers Media, 2018)
ENGLISH ABSTRACT: In high burden settings, the risk of infection with Mycobacterium tuberculosis increases throughout childhood due to cumulative exposure. However, the risk of progressing from tuberculosis (TB) infection ...
Assessing the impact of multidrug-resistant tuberculosis in children : an exploratory qualitative study
(BioMed Central, 2014-08)
Background: While the prevalence of multidrug-resistant (MDR) tuberculosis (TB) is high among children in the Western Cape of South Africa, the psychosocial implications of treatment for children with MDR-TB remain ...