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Larger subcortical gray matter structures and smaller corpora callosa at age 5 years in HIV infected children on early ART

Randall, Steven R.; Warton, Christopher M. R.; Holmes, Martha J.; Cotton, Mark F.; Laughton, Barbara; Van der Kouwe, Andre J. W.; Meintjes, Ernesta M. (Frontiers Media, 2017)

Sub-Saharan Africa is home to 90% of HIV infected (HIV+) children. Since the advent of antiretroviral therapy (ART), HIV/AIDS has transitioned to a chronic condition where central nervous system (CNS) damage may be ongoing. ...

Universal children’s day : let’s improve current interventions to reduce vertical transmission of HIV now

Cotton, Mark F.; Rabie, Helena (International AIDS society, 2014-11-20)

By 2013, there was a 40% decline in new paediatric infections compared to 2009. Prevention of mother to child transmission (PMTCT) of HIV continues to reduce the frequency of HIV in infants through wider and earlier ...

Treatment of young children with HIV infection : using evidence to inform policymakers

Prendergast, A. J.; Penazzato, M.; Cotton, M. F.; Musoke, P.; Mulenga, V.; Abrams, E. J.; Gibb, D. M. (Public Library of Science, 2012-07-24)

No abstract available.

No evidence of HIV replication in children on antiretroviral therapy

Van Zyl, Gert U.; Katusiime, Mary Grace; Wiegand, Ann; McManus, William R.; Bale, Michael J.; Halvas, Elias K.; Luke, Brian; Boltz, Valerie F.; Spindler, Jonathan; Laughton, Barbara; Engelbrecht, Susan; Coffin, John M.; Cotton, Mark F.; Shao, Wei; Mellors, John W.; Kearney, Mary F. (American Society for Clinical Investigation, 2017-04)

ENGLISH ABSTRACT: It remains controversial whether current antiretroviral therapy (ART) fully suppresses the cycles of HIV replication and viral evolution in vivo. If replication persists in sanctuary sites such as the ...

Tuberculosis : opportunities and challenges for the 90-90-90 targets in HIV-infected children

Rabie, Helena; Frigati, Lisa; Hesseling, Anneke C.; Garcia-Prats, Anthony J. (International AIDS Society, 2015-12-02)

Introduction: In 2014 the Joint United Nations Programme on HIV/AIDS defined the ambitious 90 90 90 targets for 2020, in which 90% of people living with HIV must be diagnosed, 90% of those diagnosed should be on sustained ...

Effects of postnatal interventions for the reduction of vertical HIV transmission on infant growth and non-HIV infections : a systematic review

Zunza, Moleen; Mercer, Gareth D.; Thabane, Lehana; Esser, Monika; Cotton, Mark F. (BioMed Central, 2013-12-20)

Introduction: Guidelines in resource-poor settings have progressively included interventions to reduce postnatal HIV transmission through breast milk. In addition to HIV-free survival, infant growth and non-HIV infections ...

A universal testing and treatment intervention to improve HIV control : one-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial

Hayes, Richard; Floyd, Sian; Schaap, Ab; Shanaube, Kwame; Bock, Peter; Sabapathy, Kalpana; Griffith, Sam; Donnell, Deborah; Piwowar-Manning, Estelle; El-Sadr, Wafaa; Beyers, Nulda; Ayles, Helen; Fidler, Sarah (Public Library of Science, 2017)

Background: The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets require that, by 2020, 90% of those living with HIV know their status, 90% of known HIV-positive individuals receive sustained antiretroviral ...

Variation in HIV prevalence and the population-level effects of antiretroviral therapy in reducing tuberculosis incidence in South Africa

Sloot, R.; Maarman, G. J.; Osman, M.; Marx, F. M. (Health & Medical Publishing Group, 2018)

The current year (2018) marks the 10th year after the tuberculosis (TB) epidemic in South Africa (SA) reached a historic peak of 848 incident TB cases per 100 000 population in 2008.[1,2] TB incidence has since decreased ...

Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life

Laughton, Barbara; Naidoo, Shalena; Dobbels, Els; Boivin, Michael J.; Janse van Rensburg, Anita; Glashoff, Richard H.; Van Zyl, Gert U.; Kruger, Mariana; Cotton, Mark F. (AOSIS, 2019-10-03)

Background: Antiretroviral therapy (ART) started between 7 and 12 weeks of age improves neurodevelopmental outcomes in HIV-infected (HIV+) infants, but the impact of even earlier initiation is not yet described. Objectives: ...

Antiretroviral therapy for the management of HIV in children

Frigati, L.; Cotton, Mark F.; Rabie, H. (Health & Medical Publishing Group, 2014-12)

Since 2004, when antiretroviral therapy (ART) was first available to children through the National Department of Health, there has been significant progress in preventing and treating paediatric HIV. Large cohort studies ...