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The role of traditional healers in the diagnosis and management of Burkitt lymphoma in Cameroon : understanding the challenges and moving forward
(BioMed Central, 2017-04-11)
Background
Burkittlymphoma(BL) is the most common childhood cancer in Cameroon with a reported incidence of 3 per 100,000 children under 15 years in the Northwest region. Treatment at three Baptist mission hospitals has ...
Larger subcortical gray matter structures and smaller corpora callosa at age 5 years in HIV infected children on early ART
(Frontiers Media, 2017)
Sub-Saharan Africa is home to 90% of HIV infected (HIV+) children. Since the advent of antiretroviral therapy (ART), HIV/AIDS has transitioned to a chronic condition where central nervous system (CNS) damage may be ongoing. ...
The PREVENT study to evaluate the effectiveness and acceptability of a community-based intervention to prevent childhood tuberculosis in Lesotho : study protocol for a cluster randomized controlled trial
(BioMed Central, 2017-11-21)
Background:
Effective, evidence-based interventions to prevent childhood tuberculosis (TB) in high TB/HIV-burden, resource-limited settings are urgently needed. There is limited implementation of evidence-based contact ...
Cerebrospinal fluid amino acid profiling of pediatric cases with tuberculous meningitis
(Frontiers Media, 2017)
Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of ...
White matter abnormalities in children with HIV infection and exposure
(Frontiers Media, 2017)
Background: Due to changes in guidelines and access to treatment, more children start combination antiretroviral therapy (ART) in infancy. With few studies examining the long-term effects of perinatal HIV infection and ...
Incomplete childhood immunization in Nigeria: a multilevel analysis of individual and contextual factors
(BioMed Central, 2017-03)
ENGLISH SUMMARY : Background: Under-five mortality remains high in sub-Saharan Africa despite global decline. One quarter of these deaths are preventable through interventions such as immunization. The aim of this study ...
Effectiveness of the 13-valent pneumococcal conjugate vaccine against invasive pneumococcal disease in South African children : a case-control study
(Elsevier, 2017-01-27)
Background: The 13-valent pneumococcal conjugate vaccine (PCV13) was designed to include disease-causing
serotypes that are important in low-income and middle-income countries. Vaccine eff ectiveness estimates are scarce
in ...
Cross‐cultural assessment of HIV‐associated cognitive impairment using the Kaufman assessment battery for children : a systematic review
(Wiley Open Access, 2017)
Introduction: Despite improved efficacy of, and access to, combination antiretroviral therapy (cART), HIV‐associated cognitive impairments remain prevalent in both children and adults. Neuropsychological tests that detect ...
No evidence of HIV replication in children on antiretroviral therapy
(American Society for Clinical Investigation, 2017-04)
ENGLISH ABSTRACT: It remains controversial whether current antiretroviral therapy (ART) fully suppresses the cycles of HIV replication and viral evolution in vivo. If replication persists in sanctuary sites such as the ...
Obstructive pulmonary disease in patients with previous tuberculosis : pathophysiology of a community-based cohort
(Health & Medical Publishing Group, 2017)
Background. An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are ...