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Aminoglycoside-induced hearing loss in HIV-positive and HIV-negtive multidrug-resistant tuberculosis patients
(Health and Medical Publishing Group (HMPG), 2012-06)
Background. Ototoxicity following aminoglycoside treatment
for multidrug-resistant tuberculosis (MDR-TB), is a significant
problem. This study documents the incidence of ototoxicity in HIVpositive
and HIV-negative ...
Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes : an individual patient data meta-analysis of 9,153 patients
(Public Library of Science, 2012-08-28)
Background: Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of ...
Treatment and outcomes in children with multidrug-resistant tuberculosis : a systematic review and individual patient data meta-analysis.
(Public Library of Science, 2018-07-11)
Background:
An estimated 32,000 children develop multidrug-resistant tuberculosis (MDR-TB; Mycobacterium
tuberculosis resistant to isoniazid and rifampin) each year. Little is known about the
optimal treatment for these ...
Tuberculosis disease during pregnancy and treatment outcomes in HIV-infected and uninfected women at a referral hospital in Cape Town
(Public Library of Science, 2016)
Background:
Tuberculosis during pregnancy and treatment outcomes are poorly defined in high prevalence tuberculosis and HIV settings.
Methods:
A prospective cohort study of pregnant and postpartum women identified ...
Isoniazid preventive therapy in HIV-infected and -uninfected children (0 - 14 years)
(Health & Medical Publishing Group, 2013-09-04)
Isoniazid preventive therapy (IPT) prevents tuberculosis (TB) in immunocompetent children <5 years of age after exposure to an infectious TB source case. Routine IPT has been advocated in all HIV-infected children without ...
Drug-resistant tuberculosis and advances in the treatment of childhood tuberculosis
(BioMed Central, 2016-11-24)
Over the last 10 years, interest in pediatric tuberculosis (TB) has increased dramatically, together with increased
funding and research. We have a better understanding of the burden of childhood TB as well as a better ...
Assessing the impact of multidrug-resistant tuberculosis in children : an exploratory qualitative study
(BioMed Central, 2014-08)
Background:
While the prevalence of multidrug-resistant (MDR) tuberculosis (TB) is high among children in the Western Cape of South Africa, the psychosocial implications of treatment for children with MDR-TB remain ...
Risk factors for infection and disease in child contacts of multidrug-resistant tuberculosis : a cross-sectional study
(BioMed Central, 2013-08)
Background: Young children exposed to Mycobacterium tuberculosis have a high risk of disease progression
following infection. This study aimed to determine risk factors for M. tuberculosis infection and disease in children ...
Novel application of NIH case definitions in a paediatric tuberculosis contact investigation study
(International Union Against Tuberculosis and Lung Disease, 2015-04)
BACKGROUND:
International (National Institutes of Health [NIH]) case definitions have been proposed for paediatric tuberculosis (TB) diagnostic studies. The relevance of these definitions for contact tracing studies is ...
Pediatric multidrug-resistant tuberculosis clinical trials : challenges and opportunities
(Elsevier on behalf of International Society for Infectious Diseases, 2017)
On June 17, 2016, RESIST-TB, IMPAACT, Vital Strategies, and New Ventures jointly hosted the Pediatric Multidrug Resistant Tuberculosis Clinical Trials Landscape Meeting in Arlington, Virginia, USA. The meeting provided ...