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A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness

Bardien, Soraya; Human, Hannique; Harris, Tashneem; Hefke, Gwynneth; Veikondis, Rene; Schaaf, H. Simon; Van der Merwe, Lize; Greinwald, John H.; Fagan, Johan; De Jong, Greetje (BioMed Central, 2009-01)

Background: South Africa has one of the highest incidences of multidrug-resistant tuberculosis (MDR-TB) in the world. Concomitantly, aminoglycosides are commonly used in this country as a treatment against MDR-TB. To date, ...

Drug-resistant tuberculosis in children

Schaaf, H. Simon (Health and Medical Publishing Group (HMPG), 2007-10)

Clinical presentation and outcome of tuberculosis in human immunodeficiency virus infected children on anti-retroviral therapy

Walters, Elisabetta; Cotton, Mark F.; Rabie, Helena; Schaaf, H. Simon; Walters, Lourens O.; Marais, Ben J. (BioMed Central, 2008-01)

Background: The tuberculosis (TB) and human immunodeficiency virus (HIV) epidemics are poorly controlled in sub-Saharan Africa, where highly active antiretroviral treatment (HAART) has become more freely available. Little ...

Human immunodeficiency virus infection and child sexual abuse

Schaaf, H. Simon (Health and Medical Publishing Group (HMPG), 2004-09)

BCG vaccination in South African HIV-exposed infants : risks and benefits

Hesseling, A. C.; Caldwell, J.; Cotton, M. F.; Eley, B. S.; Jaspan, H. B.; Jennings, K.; Marais, B. J.; Nuttall, J.; Rabie, H.; Roux, P.; Schaaf, H. Simon (Health and Medical Publishing Group (HMPG), 2009-02)

Adherence to isoniazid preventive chemotherapy: a prospective community based study

Marais, B. J.; Van Zyl, S.; Schaaf, H. Simon; Van Aardt, M. C.; Gie, R. P.; Beyers, Nulda (BMJ Publishing Group, 2006-09)

Background: Current international guidelines recommend 6–9 months of isoniazid (INH) preventive chemotherapy to prevent the development of active tuberculosis in children exposed to a susceptible strain of M tuberculosis. ...

The prevalence of symptoms associated with pulmonary tuberculosis in randomly selected children from a high burden community

Marais, B. J.; Obihara, C. C.; Gie, R. P.; Schaaf, H. Simon; Hesseling, A. C.; Lombard, C.; Enarson, D.; Bateman, E.; Beyers, Nulda (BMJ Publishing Group, 2005-11)

Background: Diagnosis of childhood tuberculosis is problematic and symptom based diagnostic approaches are often promoted in high burden settings. This study aimed (i) to document the prevalence of symptoms associated ...

Unexplained HIV-1 infection in children : documenting cases and assessing for possible risk factors

Hiemstra, R.; Rabie, H.; Schaaf, H. Simon; Eley, B.; Cameron, N.; Mehtar, Shaheen; Janse van Rensburg, A.; Cotton, M. F. (Health and Medical Publishing Group (HMPG), 2004-03)

Background. In the year 2000 we reported possible horizontal transmission of HIV-1 infection between two siblings. An investigation of three families, each with an HIV-infected child but seronegative parents, permitted ...