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Diabetes mellitus and male infertility

dc.contributor.authorOmolaoye, Temidayoen_ZA
dc.contributor.authorDu Plessis, Stefan S.en_ZA
dc.date.accessioned2019-08-27T09:19:35Z
dc.date.available2019-08-27T09:19:35Z
dc.date.issued2018
dc.identifier.citationOmolaoye, T. & Du Plessis, S. S. 2018. Diabetes mellitus and male infertility. Asian Pacific Journal of Reproduction, 7(1):6-14, doi:10.4103/2305-0500.220978.
dc.identifier.otherdoi:10.4103/2305-0500.220978
dc.identifier.urihttp://hdl.handle.net/10019.1/106380
dc.descriptionCITATION: Omolaoye, T. & Du Plessis, S. S. 2018. Diabetes mellitus and male infertility. Asian Pacific Journal of Reproduction, 7(1):6-14, doi:10.4103/2305-0500.220978.
dc.descriptionThe original publication is available at http://www.apjr.net
dc.description.abstractENGLISH ABSTRACT: Infertility is prevalent in about 10%-25% of couples in their reproductive age, analogous to 60-80 million infertile couples globally. Of these infertility cases, 10%-30% are exclusively attributed to a problem of the male. Several diseases have been implicated as contributors to deteriorating male fertility and diabetes mellitus (DM) is included. DM, a chronic noncommunicable disease, has been considered as one of the most appreciable health threats, as it affects 9% (422 million) of the world’s population as of 2014. It is characterised by hyperglycaemia, which can result from the inability of the pancreatic毬-cells to secrete insulin or from the target tissue becoming insensitive to insulin. DM has been reported to influence male reproductive function through diverse pathways and mechanisms. The adverse effects of reactive oxygen species and successive development of oxidative stress that occur due to DM have been investigated and implicated by several studies. The products of nonenzymatic glycosylation are reported to be widely distributed in the reproductive tract of diabetic men. Additionally, DM has been implicated to impair the processes of male sexual acts. Data reported in this review were extracted from PubMed, Google Scholar, Science Direct and Scopus with diabetes and male infertility as the key search words. In light of the aforementioned, the aim of this review is to provide brief background information on DM as well highlight and explain the likely mechanisms of male fertility which DM impacts.en_ZA
dc.format.extent9 pagesen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherMedknowen_ZA
dc.subjectDiabetes mellitusen_ZA
dc.subjectMale infertilityen_ZA
dc.subjectDiabetic neuropathyen_ZA
dc.subjectOxidative stressen_ZA
dc.titleDiabetes mellitus and male infertilityen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyrighten_ZA


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