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The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection

dc.contributor.authorVanker, N.en_ZA
dc.contributor.authorIpp, H.en_ZA
dc.date.accessioned2018-09-17T11:52:59Z
dc.date.available2018-09-17T11:52:59Z
dc.date.issued2014
dc.identifier.citationVanker, N. & Ipp, H. 2014. The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection. South African Medical Journal, 104(1), doi::10.7916/SAMJ.6983.
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.otherdoi:10.7916/SAMJ.6983
dc.identifier.urihttp://hdl.handle.net/10019.1/104440
dc.descriptionCITATION: Vanker, N. & Ipp, H. 2014. The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection. South African Medical Journal, 104(1), doi::10.7916/SAMJ.6983.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractBackground. A feature of HIV/AIDS is chronic immune activation, which results in a number of complications including inflammation-related disorders and blood cytopaenias. Immune activation status is not routinely tested in HIV infection. However, the full blood count (FBC) is a commonly performed test. Objective. We hypothesised that FBC parameters would be significantly different in HIV-infected v. -uninfected individuals, and that some of these parameters would correlate with markers of immune activation (i.e. percentage CD38 expression on CD8+ T cells (%CD38onCD8)) and disease progression (i.e. CD4+ counts) in HIV infection. Methods. This was a cross-sectional study with 83 HIV-infected adults who were antiretroviral therapy-naive and clinically well, and 51 HIV-uninfected adults. The %CD38onCD8 and CD4+ counts were determined by flow cytometry and the FBC was performed on a Siemens ADVIA 2120 system. FBC parameters investigated were total white cell count (WCC), haemoglobin (Hb) concentration, platelet count, absolute neutrophil count, absolute lymphocyte count, and percentage of large unstained cells (%LUCs). Results. Significant differences were found between the HIV-infected and -uninfected groups for total WCC, Hb, neutrophil count, lymphocyte count and %LUCs. The mean ± standard deviation (SD) for the total WCC (5.3±1.3 v. 6.9±2.2; p≤0.001) and the %LUCs (2.5±0.9 v. 2.0±0.9; p=0.001) both showed correlations with CD4+ counts and %CD38onCD8. Conclusion. The total WCC and %LUCs showed significant differences in HIV-infected individuals and correlated with markers of immune activation and disease progression. This suggests the potential use of these parameters as markers of immune activation in HIV infection.en_ZA
dc.description.urihttp://www.samj.org.za/index.php/samj/article/view/12355
dc.format.extent4 pages
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Group
dc.subjectHIV infectionsen_ZA
dc.subjectBlood cellsen_ZA
dc.titleThe use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infectionen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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