Tranexamic acid for preventing postpartum haemorrhage

Cluver, Catherine Anne ; Novikova, Natalia ; Hofmeyr, George Justus (2015-06-16)

CITATION: Novikova, N, Hofmeyr, G. J. & Cluver, C. A. 2015. Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database of Systematic Reviews, 6: Art. No.: CD007872, doi:10.1002/14651858.CD007872.pub3.

The original publication is available at https://www.cochranelibrary.com

Article

Background: Postpartum haemorrhage (PPH) is a common and potentially life-threatening complication of labour. Several options for preventing PPH are available, but further advances in this field are important, especially the identification of safe, easy to use and cost-effective regimens. Tranexamic acid (TA), which is an antifibrinolytic agent that is used widely to prevent and treat haemorrhage, merits evaluation to assess whether it meets these criteria. Objectives: To determine, from the best available evidence, whether TA is effective and safe for preventing PPH in comparison to placebo or no treatment (with or without uterotonic co-treatment), or to uterotonic agents.

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