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Epidemiology of rubella infection in Cameroon : a 7-year experience of measles and rubella case-based surveillance, 2008–2014

dc.contributor.authorNimpa Mengouo, Marcellinen_ZA
dc.contributor.authorNdze, Valantine Ngumen_ZA
dc.contributor.authorBaonga, Frangyen_ZA
dc.contributor.authorKobela, Marieen_ZA
dc.contributor.authorWiysonge, Charles Sheyen_ZA
dc.date.accessioned2018-08-15T10:01:15Z
dc.date.available2018-08-15T10:01:15Z
dc.date.issued2017-04
dc.identifier.citationNimpa Mengouo, M. et al. 2017. Epidemiology of rubella infection in Cameroon: a 7-year experience of measles and rubella case-based surveillance, 2008–2014. BMJ Open, 7(4):e012959. doi:10.1136/bmjopen-2016-012959.en_ZA
dc.identifier.issn2044-6055 (online)
dc.identifier.otherdoi:10.1136/bmjopen-2016-012959
dc.identifier.urihttp://hdl.handle.net/10019.1/104267
dc.descriptionCITATION: Nimpa Mengouo, M. et al. 2017. Epidemiology of rubella infection in Cameroon: a 7-year experience of measles and rubella case-based surveillance, 2008–2014. BMJ Open, 7(4):e012959. doi:10.1136/bmjopen-2016-012959.en_ZA
dc.descriptionThe original publication is available at https://bmjopen.bmj.com/en_ZA
dc.description.abstractObjective The aim of this study was to estimate the proportion of rubella disease in a measles case-based surveillance in Cameroon prior to rubella vaccine introduction into the national immunisation programme. Design This was a cross-sectional study for rubella infection in Cameroon for the period 2008 to 2014. Setting Patients suspected with measles from the 10 regions of Cameroon were recruited according to the WHO measles case definition and were tested for rubella IgM antibodies accompanied with the case report/investigation forms. Participants All persons with rash and fever within 14 days of onset of rash according to the standard WHO African Regional Office (WHO/AFRO) case definition for a suspected measles case. Outcome measures Descriptive analyses and simple logistic regressions were performed. OR were estimated. Results A total of 9907 serum samples from people with fever and rash were received in the laboratory from 2008 to 2014. A total of 7489 (75.59%) measles-negative samples were tested for rubella; 699 (9.3%) were positive for rubella IgM antibodies. Logistic regression analysis was done using IgM antibodies detection as the outcome variable. Age, sex and setting were explanatory variables. Logistic regression analysis revealed that, comparing the proportion of rubella IgM seropositivity status by age, the association to a positive rubella IgM increased with age from 1 to 4 years (OR 7.11; 95% CI 4.35 to 12.41; p<0.0001), through 5 to 9 years (OR 13.07; 95% CI 7.93 to 22.93; p<0.001), to 10 to 14 years of age (OR 13.86; 95% CI 8.06 to 25.12; p<0.001). Persons aged ≥15 years were also more likely to have rubella infection than children under one (OR 3.69; 95% CI 1.85 to 7.48; p=0.0001). There were also significant associations with sex, with males being less associated to a positive rubella serology than females (OR 1.33; 95% CI 1.14 to 1.56; p=0.0001). No statistically significant difference in proportion of rubella cases was observed between urban and rural populations (OR 1.11; 95% CI 0.94 to 1.31; p=0.208). Conclusions This study reveals that rubella virus circulates in Cameroon, with important number of cases in children under 15 years. This finding supports the planned introduction of rubella-containing vaccines into the Expanded Program on Immunization.en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherBMJ Publishing Group
dc.subjectRubellaen_ZA
dc.subjectMeasles virusen_ZA
dc.subjectInfectious diseasesen_ZA
dc.titleEpidemiology of rubella infection in Cameroon : a 7-year experience of measles and rubella case-based surveillance, 2008–2014en_ZA
dc.typeArticleen_ZA
dc.description.versionpublishers versionen_ZA
dc.rights.holderAuthors retain copyright


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