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Rutin as a potent antioxidant : implications for neurodegenerative disorders

dc.contributor.authorEnogieru, Adaze Bijouen_ZA
dc.contributor.authorHaylett, Williamen_ZA
dc.contributor.authorHiss, Donavon Charlesen_ZA
dc.contributor.authorBardien, Sorayaen_ZA
dc.contributor.authorEkpo, Okobi Ekoen_ZA
dc.date.accessioned2018-07-19T09:42:08Z
dc.date.available2018-07-19T09:42:08Z
dc.date.issued2018
dc.identifier.citationEnogieru, A. B., et al. 2017. Rutin as a potent antioxidant : implications for neurodegenerative disorders. Oxidative Medicine and Cellular Longevity, Article ID 6241017, doi:10.1155/2018/6241017
dc.identifier.issn1942-0994 (online)
dc.identifier.issn1942-0900 (print)
dc.identifier.otherdoi:10.1155/2018/6241017
dc.identifier.urihttp://hdl.handle.net/10019.1/104167
dc.descriptionCITATION: Enogieru, A. B., et al. 2017. Rutin as a potent antioxidant : implications for neurodegenerative disorders. Oxidative Medicine and Cellular Longevity, Article ID 6241017, doi:10.1155/2018/6241017.
dc.descriptionThe original publication is available at https://www.hindawi.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.
dc.description.abstractA wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, and inflammation. Intervention strategies using plant-derived bioactive compounds have been offered as a form of treatment for these debilitating conditions, as there are currently no remedies to prevent, reverse, or halt the progression of neuronal loss. Rutin, a glycoside of the flavonoid quercetin, is found in many plants and fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, and oranges. Pharmacological studies have reported the beneficial effects of rutin in many disease conditions, and its therapeutic potential in several models of NDs has created considerable excitement. Here, we have summarized the current knowledge on the neuroprotective mechanisms of rutin in various experimental models of NDs. The mechanisms of action reviewed in this article include reduction of proinflammatory cytokines, improved antioxidant enzyme activities, activation of the mitogen-activated protein kinase cascade, downregulation of mRNA expression of PD-linked and proapoptotic genes, upregulation of the ion transport and antiapoptotic genes, and restoration of the activities of mitochondrial complex enzymes. Taken together, these findings suggest that rutin may be a promising neuroprotective compound for the treatment of NDs.en_ZA
dc.description.urihttps://www.hindawi.com/journals/omcl/2018/6241017/
dc.format.extent18 pages
dc.language.isoen_ZAen_ZA
dc.publisherHindawi
dc.subjectNervous system -- Degenerationen_ZA
dc.titleRutin as a potent antioxidant : implications for neurodegenerative disordersen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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