Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Abstract
The thrombin-induced polymerisation of fibrinogen to form fibrin is well established as a late stage of blood clotting. It is known that Parkinson’s Disease (PD) is accompanied by dysregulation in blood clotting, but it is less widely known as a coagulopathy. In recent work, we showed that the presence of tiny amounts of bacterial lipopolysaccharide (LPS) in healthy individuals could cause clots to adopt an amyloid form, and this could be observed via scanning electron microscopy (SEM) or via the fluorescence of thioflavin-T. This could be prevented by the prior addition of lipopolysaccharide-binding protein (LBP). We had also observed by SEM this unusual clotting in the blood of patients with Parkinson’s Disease. We hypothesised, and here show, that this too can be prevented by LBP in the context of PD. This adds further evidence implicating inflammatory microbial cell wall products as an accompaniment to the disease, and may be part of its aetiology. This may lead to novel treatment strategies in PD designed to target microbes and their products.
Description
CITATION: Pretorius, E., et al. 2018. Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLoS ONE, 13(3):e0192121, doi:10.1371/journal.pone.0192121.
The original publication is available at http://journals.plos.org/plosone
Publication of this article was funded by the Stellenbosch University Open Access Fund.
The original publication is available at http://journals.plos.org/plosone
Publication of this article was funded by the Stellenbosch University Open Access Fund.
Keywords
Parkinson’s disease, Lipopolysaccharide-binding protein (LBP), Scanning electron microscopy (SEM), Parkinson's disease -- Treatment
Citation
Pretorius, E., et al. 2018. Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLoS ONE, 13(3):e0192121, doi:10.1371/journal.pone.0192121