Release of bacteriocins from nanofibers prepared with combinations of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO)

Heunis, Tiaan ; Bshena, Osama ; Klumperman, Bert ; Dicks, Leon (2011)

CITATION: Heunis, T., et al. 2011. Release of bacteriocins from nanofibers prepared with combinations of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO). International Journal of Molecular Sciences, 12(4):2158-2173, doi:10.3390/ijms12042158.

The original publication is available at http://www.mdpi.com

Article

Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(D,L-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 °C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications.

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