The impact of HIV infection on the presentation of lung cancer in South Africa

Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Health & Medical Publishing Group
Abstract
ENGLISH ABSTRACT: Background. Despite the very high background prevalence of HIV and smoking-related diseases in sub-Saharan Africa, very little is known about the presentation of lung cancer in HIV-infected individuals. Methods. We prospectively compared HIV-positive (n=44) and HIV-negative lung cancer patients (n=425) with regard to demographics, cell type, performance status and umour node metastasis staging at initial presentation. Results. HIV-positive patients were found to be younger than HIV-negative (mean 54.1 (standard deviation (SD) 8.4) years v. 60.5 (10) years, p<0.01), more likely to have squamous cell carcinoma (43.2% v. 30.1%, p=0.07) and significantly more likely to have a poor Eastern Cooperative Oncology Group (ECOG) performance status of ≥3 (47.7% v. 29.4%, p=0.02). In the case of non-small cell-lung cancer, they were also significantly less likely to have early stage lung cancer (0% v. 10.3%, p=0.02) compared with HIV-negative patients. Conclusions. HIV-positive lung cancer patients were younger, significantly more likely to have a poor performance status at presentation and significantly less likely to have early stage lung cancer when compared with HIV-negative patients.
AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar
Description
CITATION: Koegelenberg, C. F. N., et al. 2016. The impact of HIV infection on the presentation of lung cancer in South Africa. South African Medical Journal, 106(7):666-668, doi:10.7196/SAMJ.2016.v106i7.10737.
The original publication is available at http://www.samj.org.za
Keywords
HIV-positive persons, Lung cancer, Bronchoscopy
Citation
Koegelenberg, C. F. N., et al. 2016. The impact of HIV infection on the presentation of lung cancer in South Africa. South African Medical Journal, 106(7):666-668, doi:10.7196/SAMJ.2016.v106i7.10737