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Endocrine and immune effects of dexamethasone in unilateral total knee replacement

dc.contributor.authorSmith, Carineen_ZA
dc.contributor.authorErasmus, P. J.en_ZA
dc.contributor.authorMyburgh, K. H.en_ZA
dc.date.accessioned2017-09-07T07:57:49Z
dc.date.available2017-09-07T07:57:49Z
dc.date.issued2006
dc.identifier.citationSmith, C., Erasmus, P. J. & Myburgh, K. H. 2006. Endocrine and immune effects of dexamethasone in unilateral total knee replacement. Journal of International Medical Research, 34(6):603-11, doi:10.1177/147323000603400605
dc.identifier.issn1473-2300 (online)
dc.identifier.issn0300-0605 (print)
dc.identifier.otherdoi:10.1177/147323000603400605
dc.identifier.urihttp://hdl.handle.net/10019.1/102198
dc.descriptionCITATION: Smith, C., Erasmus, P. J. & Myburgh, K. H. 2006. Endocrine and immune effects of dexamethasone in unilateral total knee replacement. Journal of International Medical Research, 34(6):603-11, doi:10.1177/147323000603400605.
dc.descriptionThe original publication is available at http://journals.sagepub.com
dc.description.abstractThe effect of acute pre-surgery dexamethasone treatment on the inflammatory immune and endocrine responses to orthopaedic surgery was investigated. Whole blood samples were obtained before and 5 days after surgery for immune analysis, and serum was obtained before and 6 h, 3 days and 5 days after surgery for endocrine assessment. Dexamethasone did not affect the post-surgery granulocyte response, but inhibited the increase in monocyte count (an average increase of 38.5% was seen in the control group). Peak C-reactive protein concentration (3 days after surgery) was 51.4% lower in the dexamethasone group than in the control group. Dexamethasone had a major effect on cortisol concentrations and the cortisol:testosterone and cortisol: dehydroepiandrosterone ratios, but no effect on anabolic hormone concentrations. In conclusion, acute pre-surgery dexamethasone reatment may have beneficial effects in the post-surgery period, by limiting the extent of systemic inflammation and the cortisol response.en_ZA
dc.description.urihttp://journals.sagepub.com/doi/10.1177/147323000603400605
dc.format.extent9 pages
dc.language.isoen_ZAen_ZA
dc.publisherSAGE Publications
dc.subjectDexamethasoneen_ZA
dc.titleEndocrine and immune effects of dexamethasone in unilateral total knee replacementen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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