Endocrine and Immune Effects of Dexamethasone in Unilateral Total Knee Replacement

Smith, Carine ; Erasmus, P. J. ; Myburgh, K. H. (2006)


The effect of acute pre-surgery dexamethasone treatment on the inflammatory immune and endocrine responses to orthopaedic surgery was investigated. Whole blood samples were obtained before and 5 days after surgery for immune analysis, and serum was obtained before and 6 h, 3 days and 5 days after surgery for endocrine assessment. Dexamethasone did not affect the post-surgery granulocyte response, but inhibited the increase in monocyte count (an average increase of 38.5% was seen in the control group). Peak C-reactive protein concentration (3 days after surgery) was 51.4% lower in the dexamethasone group than in the control group. Dexamethasone had a major effect on cortisol concentrations and the cortisol:testosterone and cortisol: dehydroepiandrosterone ratios, but no effect on anabolic hormone concentrations. In conclusion, acute pre-surgery dexamethasone reatment may have beneficial effects in the post-surgery period, by limiting the extent of systemic inflammation and the cortisol response.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/102198
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