Ageing-associated oxidative stress and inflammation are alleviated by products from grapes
Date
2016
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
Advanced age is associated with increased incidence of a variety of chronic disease states which share oxidative stress and
inflammation as causative role players. Furthermore, data point to a role for both cumulative oxidative stress and low grade
inflammation in the normal ageing process, independently of disease. Therefore, arguably the best route with which to address
premature ageing, aswell as age-associated diseases such as diabetes, cardiovascular disease, and dementia, is preventative medicine
aimed at modulation of these two responses, which are intricately interlinked. In this review, we provide a detailed account of
the literature on the communication of these systems in the context of ageing, but with inclusion of relevant data obtained in
other models. In doing so, we attempted to more clearly elucidate or identify the most probable cellular or molecular targets for
preventative intervention. In addition, given the absence of a clear pharmaceutical solution in this context, together with the everincreasing
consumer bias for natural medicine, we provide an overview of the literature on grape (Vitis vinifera) derived products,
for which beneficial effects are consistently reported in the context of both oxidative stress and inflammation.
Description
CITATION: Petersen, K. S. & Smith, C. 2016. Ageing-associated oxidative stress and inflammation are alleviated by products from grapes. Oxidative Medicine and Cellular Longevity, Article ID 6236309, doi:10.1155/2016/6236309.
The original publication is available at https://www.hindawi.com/journals/omcl
The original publication is available at https://www.hindawi.com/journals/omcl
Keywords
oxidative stress, Natural medicine
Citation
Petersen, K. S. & Smith, C. 2016. Ageing-associated oxidative stress and inflammation are alleviated by products from grapes. Oxidative Medicine and Cellular Longevity, Article ID 6236309, doi:10.1155/2016/6236309