Epidemiology of major depressive disorder in South Africa (1997 – 2015): a systematic review protocol
CITATION: Nglazi, M. D., et al. 2016. Epidemiology of major depressive disorder in South Africa (1997 – 2015) : a systematic review protocol. BMJ Open, 6:e011749, doi:10.1136/bmjopen-2016-
The original publication is available at http://bmjopen.bmj.com
ENGLISH SUMMARY : Introduction: Major depressive disorder (MDD) is a leading cause of disease and disability globally and in South Africa. Epidemiological data for MDD are essential to estimate the overall disease burden in a country. The objective of the systematic review is to examine the evidence base for prevalence, incidence, remission, duration, severity, case fatality and excess mortality of MDD in South Africa from 1997 to 2015. Methods and analysis: We will perform electronic searches in PubMed, PsycINFO, Scopus and other bibliographical databases. Articles published between January 1997 and December 2015 will be eligible for inclusion in this review. The primary outcomes will be prevalence, incidence, remission, duration, severity, case fatality and excess mortality of MDD. The secondary outcomes will be risk factors and selected populations for MDD. If appropriate, a meta-analysis will be performed. If a meta-analysis is not possible, the review findings will be presented narratively and in tables. Subgroup analyses will be conducted with subgroups defined by population group, rural/urban settings and study designs, if sufficient data are available.