Stellenbosch University - Scopus Tygerberg Hospital Publications

Permanent URI for this collection

https://scholar.sun.ac.za/handle/10019.1/8522

Metadata of articles were exported on 14 May 2011 from Scopus. Full text to be attached and moved to relevant Research Articles Collections per Department - Inquiries: SUNScholar or Tel.: 021 808 9139/9046.

Browse

Browsing Stellenbosch University - Scopus Tygerberg Hospital Publications by browse.metadata.type "Short Survey"

Now showing 1 - 7 of 7
  • No Thumbnail Available
    Item
    A South African national database in cardiothoracic surgery
    (2010) Linegar A.; Smit F.; Stroebel A.; Schaafsma E.
    This article aims to update South African cardiothoracic surgeons on the developmental progress of the national database in cardiac and thoracic surgery and to encourage participation in this most important endeavour.
  • No Thumbnail Available
    Item
    Diarrhoea and malnutrition
    (2010) Nel E.D.
    The relationship between diarrhoea and malnutrition is bidirectional: diarrhoea leads to malnutrition while malnutrition aggravates the course of diarrhoea. Many factors contribute to the detrimental effect of diarrhoea on nutrition. Reduced intake (due to anorexia, vomiting, and withholding of feeds), maldigestion, malabsorption, increased nutrient losses, and the effects of the inflammatory response are some of the factors involved. High volume stool losses (greater than 30 ml/kg/day) are associated with a negative balance for protein, fat, and sugar absorption. Enteric infections often cause increased loss of endogenous proteins, particularly after invasive bacterial infections. Initially, the major emphasis of treatment of acute diarrhoea in children is the prevention and treatment of dehydration, electrolyte abnormalities and comorbid conditions. The objectives of diarrhoeal disease management are to prevent weight loss, to encourage catch-up growth during recovery, to shorten the duration and to decrease the impact of the diarrhoea on the child's health. Addressing only diarrhoea or only food security is unlikely to be successful in decreasing the prevalence of malnutrition. Existing evidence provides some guidelines as to the optimal nutritional management of children with diarrhoea and novel treatments may prove to be valuable in future.
  • No Thumbnail Available
    Item
    Management of patients with early severe pre-eclampsia
    (1996) Odendaal H.J.
    [No abstract available]
  • No Thumbnail Available
    Item
    Rapid thrombophilia genetic test facilitates improved prenatal care for mother and child
    (2005) Kotze M.J.; La Grange C.; Mansvelt E.P.G.; Kotze M.J.; La Grange C.; Mansvelt E.P.G.
    Physiological changes in coagulation factors during pregnancy are important to minimise blood loss during gestation and delivery, but may also lead to a 4-6 fold increased risk of venous thromboembolism during pregnancy and after delivery. Approximately 25% of maternal mortality can be ascribed to thromboembolism if untreated, while this figure is reduced to less than 1% when diagnosed on time. Clinical diagnosis is complicated by the fact that the symptoms associated with venous thrombosis are relatively common complaints of pregnant women. A rapid genetic test has been developed for simultaneous detection of the most common genetic risk factors associated with thrombophilia, the factor V 1691GA (Leiden) and prothrombin 20210GA mutations. Mutation 677CT in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which increases homocysteine levels by 15-25% when two copies of the T-allele is present, is also included as part of this "prenatal care genetic test". Hyperhomocysteinaemia has been associated with an increased risk of thrombosis and neural tube defects. The importance of multi-gene testing is emphasised by the low predictive value of any single inherited marker and the significant increase in the probability of thrombosis when more than one risk factor is identified.
  • No Thumbnail Available
    Item
    Sublethal oxygens deficiency - The primary cause of cancer
    (2000) Macfarlane C.M.
    [No abstract available]
  • No Thumbnail Available
    Item
    Testicular function after torsion of the spermatic cord
    (2003) Visser A.J.; Heyns C.F.
    [No abstract available]
  • No Thumbnail Available
    Item
    Transferrin C2 and Alzheimer's disease: Another piece of the puzzle found?
    (1995) Van Rensburg S.J.
    A significant increase in the occurrence of the transferrin C2 genetic subtype has been found in patients with Alzheimer's disease. This variant has previously been linked to diseases thought to be associated with free radical damage. We hypothesize that Alzheimer's disease is caused by free radical damage to membranes of endocytic vesicles due to defective binding of iron and aluminium by Tf C2. The aluminium binds to the membranes, creating pores, while the iron reacts with H2O2 and superoxide radicals produced by activated microglia (brain phagocytes), to produce hydroxyl radicals (oxidative toxins), which attack the fatty acids in the membranes through these pores. In order to treat the disease successfully, it would be necessary to alleviate the multiple deficiencies caused by these toxins by constantly providing the cells with antioxidants and other essential nutrients. In addition, a drug that would stimulate the regrowth of neurons is needed.