Browsing by Author "Wium, C. A."
Now showing 1 - 5 of 5
Results Per Page
Sort Options
- ItemBerg adder (Bitis atropos) : an unusual case of acute poisoning(Health and Medical Publishing Group, 2017) Wium, C. A.; Marks, C. J.; Du Plessis, C. E.; Muller, G. J.A 5-year-old boy presented to hospital with mild local cytotoxic and severe neurotoxic symptoms. The neurotoxic symptoms included ptosis, fixed dilated pupils and flaccid paralysis with respiratory failure. Mild hyponatraemia was also a clinical feature. After various unsuccessful treatment options were followed, the Tygerberg Poison Information Centre was contacted and a diagnosis of berg adder bite was made. Berg adder bites are uncommon and therefore not usually considered in the differential diagnosis of a patient presenting with an unexplained clinical picture. A timeous poison information helpline consultation is recommended in this situation.
- ItemScorpion sting in Southern Africa : diagnosis and management(Health and Medical Publishing Group (HMPG), 2012-10) Muller, G. J.; Modler, H.; Wium, C. A.; Veale, D. J. H.Most southern African scorpions are relatively harmless to humans, and although they can inflict quite a painful sting, no other toxic effects are expected to develop. However, a small number of scorpion species can cause life-threatening systemic envenoming. Children are especially vulnerable, with a mortality rate of close to 20%. Most deaths are attributable to one species, namely Parabuthus granulatus. In order for medical personnel to provide optimal patient management after a scorpion sting, they should be familiar with the clinical picture and management.
- ItemSnake bite in southern Africa : diagnosis and management(Health and Medical Publications Group (HMPG), 2012-10) Muller, G. J.; Modler, H.; Wium, C. A.; Veale, D. J. H.; Marks, C. J.Venomous snakes in southern Africa can, in broad terms, be divided into 3 groups: cytotoxic, neurotoxic and those that can induce haemostatic toxic effects. However, significant overlap of these effects may occur. Some snake species may, for example, display both cytotoxicity and neurotoxicity.
- ItemThe specific binding of the thyroid hormones to matrix isolated from rat liver nuclei(Health & Medical Publishing Group, 1982) Wilson, B. D.; Albrecht, C. F.; Wium, C. A.Specific binding sites for the thyroid hormones have been demonstrated in the liver nuclear matrix, a structural framework of the nucleus. When labelled 3,5,3'-tri-iodo-L-thyronine ([125I]T3) is injected into rats, 5% of the total nucleus bound T3 is bound to the matrix after 1 hour. However, when either isolated nuclei or isolated nuclear matrices were incubated with [125I]T3 in vitro, a 3- to 7-fold greater number of specific T3 binding sites were revealed in the nuclear matrix. The proporties of the matrix-associated thyroid hormone binding sites were investigated in vitro. These binding sites showed limited capacity and high affinity for T3; the equilibrium association constant (K(a)) was 1.3 x 109 M-1 and the binding capacity was 20.2 fmol T3 per 100 μg matrix protein.
- ItemSpider bite in southern Africa : diagnosis and management(Health and Medical Publications Group (HMPG), 2012-10) Muller, G. J.; Wium, C. A.; Marks, C. J.; Du Plessis, C. E.; Veale, D. J.The medically important spiders of southern Africa can be divided into neurotoxic and cytotoxic groups. The neurotoxic spiders belong to the genus Latrodectus (button or widow spiders) and the cytotoxic spiders are represented chiefly by the genera Cheiracanthium (sac spiders) and Loxosceles (violin or recluse spiders).