Browsing by Author "Jeena, Prakash M."

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Isoniazid preventive therapy in HIV-infected and -uninfected children (0 - 14 years)
    (Health & Medical Publishing Group, 2013-09-04) Schaaf, H. Simon; Cotton, Mark F.; Boon, Gerald P. G.; Jeena, Prakash M.
    Isoniazid preventive therapy (IPT) prevents tuberculosis (TB) in immunocompetent children <5 years of age after exposure to an infectious TB source case. Routine IPT has been advocated in all HIV-infected children without TB, but has been controversial. Antiretroviral therapy markedly reduces the risk for TB in HIV-infected children, especially when started early in infancy. In HIV-infected children, as in HIV- uninfected children, we recommend post-exposure IPT after each TB exposure episode; but in HIV-infected children, this should be given irrespective of age or antiretroviral therapy. However, evidence for routine IPT without known exposure to TB in HIV-infected children is not convincing and is therefore not recommended.