Browsing by Author "Gey van Pittius, N. C."
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- ItemEvidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent(American Society for Microbiology, 2007-07) Hanekom, M.; Van der Spuy, G. D.; Gey van Pittius, N. C.; McEvoy, C. R. E.; Ndabambi, S. L.; Victor, T. C.; Hoal, E. G.; Van Helden, Paul D.; Warren, Robin M.This study describes a comparative analysis of the Beijing mycobacterial interspersed repetitive unit types of Mycobacterium tuberculosis isolates from Cape Town, South Africa, and East Asia. The results show a significant association between the frequency of occurrence of strains from defined Beijing sublineages and the human population from whom they were cultured (P < 0.0001). Copyright © 2007, American Society for Microbiology. All Rights Reserved.
- ItemMycobacteria and disease in Southern Africa(Wiley Online Library, 2013) Botha, L.; Gey van Pittius, N. C.; Van Helden, P. D.The genus Mycobacterium consists of over 120 known species, some of which (e.g. M. bovis and M. tuberculosis) contribute extensively to the burden of infectious disease in humans and animals, whilst others are commonly found in the environment but may rarely if ever be disease‐causing. This paper reviews the mycobacteria found in southern Africa, focussing on those in the M. tuberculosis complex as well as the non‐tuberculous mycobacteria (NTM), identifying those found in the area and including those causing disease in humans and animals, and outlines some recent reports describing the distribution and prevalence of the disease in Africa. Difficulties in diagnosis, host preference and reaction, immunology and transmission are discussed.
- ItemResistance to pyrazinamide and ethambutol compromises MDR/XDR-TB treatment(Health and Medical Publishing Group (HMPG), 2009-11) Hoek, K. G. P.; Schaaf, H. S.; Gey van Pittius, N. C.; Van Helden, P. D.; Warren, R. M.