Triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa

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dc.contributor.authorWong, B. C. Y.
dc.contributor.authorChang, F. Y.
dc.contributor.authorAbid, S.
dc.contributor.authorAbbas, Z.
dc.contributor.authorLin, B. R.
dc.contributor.authorVan Rensburg, C.
dc.contributor.authorChen, P. C.
dc.contributor.authorSchneider, H.
dc.contributor.authorSimjee, A. E.
dc.contributor.authorHamid, S. S.
dc.contributor.authorSeebaran, A.
dc.contributor.authorZhang, J.
dc.contributor.authorDestefano, M.
dc.contributor.authorLam, S. K.
dc.date.accessioned2011-05-15T16:15:17Z
dc.date.available2011-05-15T16:15:17Z
dc.date.issued2000
dc.description.abstractBackground: Studies assessing the efficacy of triple therapy containing clarithromycin and amoxicillin for the eradication of Helicobacter pylori infection and healing of duodenal ulcers in Asian and African countries are limited. Aim: To determine the efficacy and safety of 1-week triple therapy with omeprazole, amoxicillin and clarithromycin for eradicating H. pylori infection in patients with active duodenal ulcer living in Asian and African regions. Methods: This was an open-label, multicentre study in 11 centres in Asia and Africa. Patients with endoscopy-proven duodenal ulcer and who were H. pylori-positive were treated with clarithromycin 500 mg, omeprazole 20 mg, and amoxicillin 1000 mg, all given twice daily for 7 days. Upper endoscopy was repeated at week 6 to check for ulcer healing and H. pylori status. Results: A total of 117 patients were recruited. H. pylori eradication rates were 85% by per protocol analysis and 80% by intention-to-treat analysis. Ulcer healing was found in 94% of subjects (per protocol analysis). Clinical success, measured by change of pre-treatment ulcer symptoms, was strongly supported by complete resolution or improvement in 100% of the evaluable patients (per protocol analysis). Since treatment-related adverse events, when present, were largely mild or moderate, the triple therapy regimen was considered safe. Conclusion: Seven-day triple therapy with omeprazole, amoxicillin, and clarithromycin was efficacious for treating Asian and African patients with duodenal ulcer disease associated with H. pylori infection, and the treatment regimen was well-tolerated.
dc.description.versionArticle
dc.identifier.citationAlimentary Pharmacology and Therapeutics
dc.identifier.citation14
dc.identifier.citation11
dc.identifier.issn02692813
dc.identifier.other10.1046/j.1365-2036.2000.00863.x
dc.identifier.urihttp://hdl.handle.net/10019.1/13274
dc.subjectamoxicillin
dc.subjectclarithromycin
dc.subjectomeprazole
dc.subjectadult
dc.subjectAfrica
dc.subjectaged
dc.subjectarticle
dc.subjectAsia
dc.subjectclinical trial
dc.subjectdiarrhea
dc.subjectdrug efficacy
dc.subjectdrug response
dc.subjectdrug safety
dc.subjectduodenum ulcer
dc.subjectgastrointestinal endoscopy
dc.subjectGram negative infection
dc.subjectHelicobacter pylori
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectnausea
dc.subjectpriority journal
dc.subjecttaste disorder
dc.subjecttreatment outcome
dc.subjectulcer healing
dc.subjectvertigo
dc.subjectAmoxicillin
dc.subjectAnti-Bacterial Agents
dc.subjectAnti-Ulcer Agents
dc.subjectClarithromycin
dc.subjectDrug Therapy, Combination
dc.subjectDuodenal Ulcer
dc.subjectHelicobacter Infections
dc.subjectHong Kong
dc.subjectHumans
dc.subjectOmeprazole
dc.subjectPakistan
dc.subjectPenicillins
dc.subjectSouth Africa
dc.subjectTaiwan
dc.subjectTreatment Outcome
dc.titleTriple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa
dc.typeArticle
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