Cavitating pulmonary tuberculosis in children: Correlating radiology with pathogenesis

Simple item page
dc.contributor.authorGriffith-Richards S.B.
dc.contributor.authorGoussard P.
dc.contributor.authorAndronikou S.
dc.contributor.authorGie R.P.
dc.contributor.authorPrzybojewski S.J.
dc.contributor.authorStrachan M.
dc.contributor.authorVadachia Y.
dc.contributor.authorKathan D.L.
dc.date.accessioned2011-05-15T16:17:41Z
dc.date.available2011-05-15T16:17:41Z
dc.date.issued2007
dc.description.abstractBackground: Cavitating pulmonary tuberculosis (PTB) is generally known as a disease of adults, with children typically having features of primary PTB. Objective: To group children with PTB and cavities according to possible pathogenesis by evaluating the clinical and radiological findings. Materials and methods: The clinical and radiological findings in ten randomly selected children with PTB and cavitations on chest radiographs were retrospectively reviewed and evaluated. Results: Three groups emerged: group 1 (four children) had cavities, usually single and unilateral in the classic upper lobe distribution of postprimary PTB; group 2 (three children) developed progressive primary spread of disease with extensive and bilateral pulmonary cavities; and group 3 (three children) developed cavities secondary to airway obstruction by mediastinal lymph nodes with consequent distal collapse and consolidation. Children in group 1 responded well to treatment and had unremarkable recoveries. Children in group 2 were all below 2 years of age with complicated recoveries. Children in group 3 had frequent complications resulting in one fatality. Conclusion: Cavities in PTB inchildren may arise by one of three possible mechanisms with a relatively equal incidence. A study is underway to determine the incidence of cavity formation associated with mediastinal lymphadenopathy and airway obstruction. © Springer-Verlag 2007.
dc.description.versionArticle
dc.identifier.citationPediatric Radiology
dc.identifier.citation37
dc.identifier.citation8
dc.identifier.issn03010449
dc.identifier.other10.1007/s00247-007-0496-z
dc.identifier.urihttp://hdl.handle.net/10019.1/14329
dc.subjectantibiotic agent
dc.subjectadolescent
dc.subjectantibiotic resistance
dc.subjectarticle
dc.subjectbacterium culture
dc.subjectchild
dc.subjectchildhood disease
dc.subjectchildhood mortality
dc.subjectclinical article
dc.subjectclinical assessment
dc.subjectclinical feature
dc.subjectcomputer assisted tomography
dc.subjectcontrolled study
dc.subjectdisease classification
dc.subjectfemale
dc.subjecthuman
dc.subjectincidence
dc.subjectinfant
dc.subjectlung tuberculosis
dc.subjectlymphadenopathy
dc.subjectmale
dc.subjectmediastinum lymph node
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectoutcome assessment
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectthorax radiography
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDiagnosis, Differential
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectMale
dc.subjectRetrospective Studies
dc.subjectTomography, X-Ray Computed
dc.subjectTuberculosis, Pulmonary
dc.titleCavitating pulmonary tuberculosis in children: Correlating radiology with pathogenesis
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications