Positive and negative symptoms in affected sib pairs with schizophrenia: Implications for genetic studies in an African Xhosa sample

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dc.contributor.authorNiehaus D.J.H.
dc.contributor.authorKoen L.
dc.contributor.authorLaurent C.
dc.contributor.authorMuller J.
dc.contributor.authorDeleuze J.-F.
dc.contributor.authorMallet J.
dc.contributor.authorSeller C.
dc.contributor.authorJordaan E.
dc.contributor.authorEmsley R.
dc.date.accessioned2011-05-15T16:02:23Z
dc.date.available2011-05-15T16:02:23Z
dc.date.issued2005
dc.description.abstractCareful phenotyping and the identification of subtypes of schizophrenia can contribute significantly to the success of genetic studies in schizophrenia. The phenomenology of schizophrenia in affected sib pairs has been well-described in Caucasian populations, however a paucity of data exists for African populations. This study therefore investigated symptom dimensions in a sizeable group of affected Xhosa sib pairs as a means of evaluating the role of shared familial factors in the psychosis of schizophrenia. Five hundred and thirteen participants were interviewed with the Diagnostic Interview for Genetic Studies (DIGS), which included the Schedules for the Assessment of Negative and Positive symptoms (SANS/SAPS). One hundred and four sib pairs were then extracted (N = 208) for analysis of concordance for lifetime psychotic symptoms and an exploratory factor analysis of the SANS/SAPS. Concordance analysis of life-time symptoms indicated a significant concordance for olfactory hallucinations, persecutory delusions, jealousy, somatic, reference and control delusions as well as thought insertion and withdrawal. The factor analysis of the global scores of the SAPS and SANS revealed a five factor best-fit model and accounted for 92.5% of variance. The factors included a negative symptom factor, a positive symptom factor, a positive thought disorder and a bizarre behaviour component. The core symptomatology of schizophrenia in this sib pair sample was similar to that reported in Caucasian populations with the exception of higher rates of auditory hallucinations and delusions of persecution. In summary therefore; although the factor analysis only supported the concept of the universality of psychotic symptoms in schizophrenia, the concordance analysis of these symptoms did reveal hallucinations as well as delusions of control as possible candidates relevant for future research into genotype-phenotype relationships. © 2005 Elsevier B.V. All rights reserved.
dc.description.versionArticle
dc.identifier.citationSchizophrenia Research
dc.identifier.citation79
dc.identifier.citation03-Feb
dc.identifier.issn9209964
dc.identifier.other10.1016/j.schres.2005.04.026
dc.identifier.urihttp://hdl.handle.net/10019.1/12440
dc.subjectadult
dc.subjectAfrica
dc.subjectarticle
dc.subjectauditory hallucination
dc.subjectCaucasian
dc.subjectcontrolled study
dc.subjectdelusion
dc.subjectfactorial analysis
dc.subjectfamilial disease
dc.subjectfemale
dc.subjectgenetics
dc.subjecthuman
dc.subjectinterview
dc.subjectjealousy
dc.subjectlifespan
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnegative syndrome
dc.subjectolfactory hallucination
dc.subjectpersecutory delusion
dc.subjectpositive syndrome
dc.subjectpriority journal
dc.subjectpsychosis
dc.subjectpsychosocial withdrawal
dc.subjectrace difference
dc.subjectschizophrenia
dc.subjectsibling
dc.subjectsomatic delusion
dc.subjectsymptom
dc.subjectsymptomatology
dc.subjectthought disorder
dc.subjectvariance
dc.subjectAdult
dc.subjectChi-Square Distribution
dc.subjectDemography
dc.subjectFactor Analysis, Statistical
dc.subjectFamily Health
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPsychiatric Status Rating Scales
dc.subjectSchizophrenia
dc.subjectSchizophrenic Psychology
dc.subjectSeverity of Illness Index
dc.subjectSibling Relations
dc.subjectSouth Africa
dc.titlePositive and negative symptoms in affected sib pairs with schizophrenia: Implications for genetic studies in an African Xhosa sample
dc.typeArticle
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