Analysis of partial gag and env gene sequences of HIV type 1 strains from southern Africa

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dc.contributor.authorBecker M.L.B.
dc.contributor.authorDe Jager G.
dc.contributor.authorBecker W.B.
dc.date.accessioned2011-05-15T16:15:17Z
dc.date.available2011-05-15T16:15:17Z
dc.date.issued1995
dc.description.abstractHIV-1 is spreading at an exponential rate in southern Africa, with a current doubling time of approximately one year. An estimated 2 million of South Africa's 36 million population are already infected with HIV. Information on the extent of variability of HIV-1 sequences in the region is important for the development of vaccines, the evaluation of new therapies, and for structure/function studies of the viral genome and proteins. The authors isolated and partially sequenced local strains of the virus. The first strain sequenced was determined to be a new subtype of HIV-1, designated subtype C(2). HIV-1 subtypes B and D are also circulating within southern Africa. The derived phylogenetic trees for the various strains are presented. It is possible that southern African HIV-1 strains have evolved from Central African ones during their spread southward over time and geographic distance. The data on HIV-1 env and gag gene variability presented in this paper have implications for the design of vaccines intended for use in southern Africa and India. The results also establish new limits of variability for the virus, by extending the phylogenetic tree along a new branch.
dc.description.versionNote
dc.identifier.citationAIDS Research and Human Retroviruses
dc.identifier.citation11
dc.identifier.citation10
dc.identifier.issn08892229
dc.identifier.urihttp://hdl.handle.net/10019.1/13270
dc.subjectgag protein
dc.subjectvirus envelope protein
dc.subjectclinical article
dc.subjectdna sequence
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman immunodeficiency virus 1
dc.subjecthuman immunodeficiency virus infection
dc.subjectmale
dc.subjectnote
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectvirus genome
dc.subjectAfrica
dc.subjectAfrica South Of The Sahara
dc.subjectBiology
dc.subjectDeveloping Countries
dc.subjectDiseases
dc.subjectEnglish Speaking Africa
dc.subjectGenetics
dc.subjectHiv
dc.subjectHiv Infections
dc.subjectResearch Report
dc.subjectSouth Africa
dc.subjectSouthern Africa
dc.subjectViral Diseases
dc.subjectAfrica, Southern
dc.subjectBase Sequence
dc.subjectFemale
dc.subjectGenes, env
dc.subjectGenes, gag
dc.subjectHIV-1
dc.subjectHuman
dc.subjectMale
dc.subjectMolecular Sequence Data
dc.subjectPhylogeny
dc.subjectSupport, Non-U.S. Gov't
dc.titleAnalysis of partial gag and env gene sequences of HIV type 1 strains from southern Africa
dc.typeNote
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