Effects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon

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dc.contributor.authorBrink, S.
dc.contributor.authorSteytler, J. G.
dc.date.accessioned2011-03-18T14:59:58Z
dc.date.available2011-03-18T14:59:58Z
dc.date.issued1974
dc.descriptionThe original version is available at http://www.samj.org.za/
dc.descriptionBibliography
dc.description.abstractThe in vitro and in vivo hematological effects of puff adder (Bitis arietans) venom in the baboon (Papio ursinus) with regard to its effect on coagulation, fibrinolysis and platelet aggregation were studied. There is a delay in the intrinsic coagulation mechanism with fibrinolysis and in vitro fibrinogenolysis. Normal human platelets demonstrated an extreme susceptibility to puff adder venom in vitro. The aggregation of platelets with small dosages of venom was irreversible. The effect is related to the dosage, and appears to be the result of multiple enzyme activities, some of which are heat labile. In minimal amounts there is evidence of consumption of blood coagulation factors with sustained thrombocytopenia, but no fibrinolysis, where heparin therapy might have a beneficial effect. With larger dosages of venom the thrombocytopenia, hemorrhagic effects and shock are not prevented or corrected by heparin and heparinisation might even be harmful. The effect of heparin should be further investigated, since it might have a place in mildly affected cases of snakebite, where absorption into the blood has been slow or intermittent. It might be indicated when antivenene is not available or when patients are sensitive to serum.
dc.description.versionPublishers'Version
dc.format.extent8 p. : ill.
dc.identifier.citationBrink, S. & Steytler, J.G. 1974, Effects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon, SA Medical Journal, 47(28), 1205-1213, http://archive.samj.org.za/
dc.identifier.issn0256-9574 (print)
dc.identifier.issn2078-5135 (online)
dc.identifier.urihttp://hdl.handle.net/10019.1/8167
dc.language.isoen_ZA
dc.publisherHealth and Medical Publishing Group (HMPG)
dc.rights.holderHealth and Medical Publishing Group (HMPG)
dc.subjectHeparin; snake venom; fibrinogen; venom; bleeding; blood clotting; fibrinogenolysis; fibrinolysis; hematology; monkey; shock; theoretical study; thrombocyte aggregation; thrombocytopenia; animal; article; baboon; blood clotting test; drug effect; female; Haplorhini; male; protein denaturation; septic shock; snake; thrombocyte adhesiveness; Animal; Blood Coagulation; Blood Coagulation Tests; Female; Fibrinogen; Fibrinolysis; Haplorhini; Hemorrhage; Heparin; Male; Papio; Platelet Adhesiveness; Protein Denaturation; Shock, Septic; Snakes; Thrombocytopenia; Venoms
dc.subjectAnimal experimentationen_ZA
dc.subjectMedical experimentation on laboratory animalsen_ZA
dc.subjectPoisonous snakes -- Effect of venom on -- Coagulationen_za
dc.subjectHeparin therapyen_ZA
dc.subjectBlood-clottingen_ZA
dc.subjectFibrinogenolysisen_ZA
dc.subjectFibrinolysisen_ZA
dc.subjectSeptic shocken_ZA
dc.titleEffects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon
dc.typeArticle
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