Pediatric tuberculosis : clinical and epidemiological reflections from a highly endemic setting

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dc.contributor.authorHesseling, Anneke
dc.date.accessioned2011-02-14T14:28:45Z
dc.date.available2011-02-14T14:28:45Z
dc.date.issued2010-12
dc.date.updated2011-02-14T11:28:09Z
dc.description.abstractPediatric TB provides unique opportunities to study TB disease epidemiology. Improved diagnostics are of key importance in order to address many of the challenges posed by TB in children. In the Western Cape Province in South Africa, the TB notification rate was more than 600 out of 100,000 for children aged 0-14 years in 2007; the maternal HIV prevalence was 15%, with a good vertical preventative program. The HIV transmission rate was 4-5%; 99% of neonates routinely receive BCG vaccination at birth. Isoniazid prophylaxis, shown to be effective in the prevention of TB in young children, is seldom initiated and many missed opportunities for preventive therapy exist. In children admitted to hospital, mycobacterial culture is routinely done for TB in children less than five years of age through gastric aspiration of stomach contents in this setting; the culture yield is 30-40% in children with clinically suspected TB.en_ZA
dc.description.versionPeer Reviewed
dc.identifier.citationHesseling, A 2010, 'Pediatric tuberculosis: clinical and epidemiological reflections from a highly endemic setting', BMC Proceedings 2010, 4(Suppl 3):O12.en_ZA
dc.identifier.other10.1186/1753-6561-4-S3-O1
dc.identifier.urihttp://hdl.handle.net/10019.1/6213
dc.language.isoen_ZAen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.rights.holderBioMed Central Ltd.en_ZA
dc.subjectPediatric TBen_ZA
dc.subjectMycobacterium tuberculosis -- Isolationen_ZA
dc.subjectDrug resistance in microorganismsen_ZA
dc.subjectBeijing strainen_ZA
dc.subjectHIV infections -- Preventionen_ZA
dc.subject.lcshTuberculosis in children -- South Africa -- Western Cape -- Treatmenten_ZA
dc.subject.lcshTuberculosis in children -- South Africa -- Western Cape -- Diagnosisen_ZA
dc.titlePediatric tuberculosis : clinical and epidemiological reflections from a highly endemic settingen_ZA
dc.typeArticleen_ZA
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Research Articles (Desmond Tutu TB Centre)