In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives

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dc.contributor.authorEvdokimov N.M.
dc.contributor.authorLamoral-Theys D.
dc.contributor.authorMathieu V.
dc.contributor.authorAndolfi A.
dc.contributor.authorFrolova L.V.
dc.contributor.authorPelly S.C.
dc.contributor.authorVan Otterlo W.A.L.
dc.contributor.authorMagedov I.V.
dc.contributor.authorKiss R.
dc.contributor.authorEvidente A.
dc.contributor.authorKornienko A.
dc.date.accessioned2012-01-18T08:06:28Z
dc.date.available2012-01-18T08:06:28Z
dc.date.issued2011
dc.descriptionPlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: scholar@sun.ac.za
dc.identifier.citationBioorganic and Medicinal Chemistry
dc.identifier.citation19
dc.identifier.citation23
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-80655146928&partnerID=40&md5=387132308634a89e1234ac70dffd5f10
dc.identifier.issn9680896
dc.identifier.other10.1016/j.bmc.2011.09.051
dc.identifier.urihttp://hdl.handle.net/10019.1/18999
dc.subject1 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl benzoate
dc.subject1 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl pivalate
dc.subject1 hydroxy 4,5,7,12b tetrahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 2(3a1h) one
dc.subject1,2 dihydroxy 3a1,4,5,12b tetrahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(2h) one
dc.subject1,2,3 trihydroxy 2,3,5,12b tetrahydroxy1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(3a1h) one
dc.subject1,2,3,4 tetrahydroxy 3,3a,3a1,4,5,12b hexahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(2h) one
dc.subject2 (triisopropylsilyloxy) 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 ol
dc.subject2 (triisopropylsilyloxy)2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl acetate
dc.subject2 (triisopropylsilyloxy)2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl palmitate
dc.subject2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl acetate
dc.subject2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl benzoate
dc.subject2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl palmitate
dc.subject2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl stearate
dc.subject2 hydroxy 4h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(5h) one
dc.subject2,3a,4,5,7,12b hexahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subject2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl dibenzoate
dc.subject3,3a dihydroxy 7 oxo 2,3,3a,3a,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subject3a hydroxy 7 oxo 2,3,3a,3a1,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,triyl triacetate
dc.subject7 oxo 2,3,3a1,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,triyl triacetate
dc.subject7 oxo 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subject7 oxo 5,7 dihydro 4h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl acetate
dc.subject7 thioxo 2,3,3a,3a1,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,3a tetraol
dc.subject7 thioxo 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subjectalkene
dc.subjectcytostatic agent
dc.subjecthydroxyl group
dc.subjectlong chain fatty acid
dc.subjectlycorine
dc.subjectpaclitaxel
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectantineoplastic activity
dc.subjectapoptosis
dc.subjectarticle
dc.subjectcancer inhibition
dc.subjectcontrolled study
dc.subjectderivatization
dc.subjectdihydroxylation
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectglioblastoma
dc.subjecthuman
dc.subjectin vitro study
dc.subjectlung non small cell cancer
dc.subjectmelanoma
dc.subjectnonhuman
dc.subjectsolid tumor
dc.subjectstructure activity relation
dc.subjecttumor cell line
dc.subjectAmaryllidaceae
dc.titleIn search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives
dc.typeArticle
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