Zinc and platelet membrane microviscosity in Alzheimer's disease. The in vivo effect of zinc on platelet membranes and cognition

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dc.contributor.authorPotocnik, F. C. V.en_ZA
dc.contributor.authorVan Rensburg, S. J.en_ZA
dc.contributor.authorPark, C.en_ZA
dc.contributor.authorTaljaard, J. J. F.en_ZA
dc.contributor.authorEmsley, R. A.en_ZA
dc.date.accessioned2011-03-18T14:57:08Z
dc.date.available2011-03-18T14:57:08Z
dc.date.issued1997
dc.descriptionCITATION: Potocnik, F. C. V. et al. 1997. Zinc and platelet membrane microviscosity in Alzheimer's disease. The in vivo effect of zinc on platelet membranes and cognition. South African Medical Journal, 87(9):1116-1119.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractObjectives. To investigate the effects of oral zinc supplementation on: (i) plasma zinc concentrations; (ii) platelet membrane microviscosity in vivo; and (iii) cognitive function of Alzheimer's disease (AD) patients. Design. An open-labelled pilot study. Setting. University of Stellenbosch Medical School and Stikland Hospital. Subjects. Six volunteer AD patients. Outcome measures. Plasma zinc levels, platelet membrane microviscosity and cognition (MMSE and ADAS-cog tests). Results. Oral zinc supplementation (30 mg/day) did not increase plasma zinc levels significantly, but significantly increased platelet membrane microviscosity (P = 0.02; 6 patients). Four patients, who underwent 12 months of evaluation, showed modest cognitive improvement on psychometric testing (Mini-Mental State Examination and the cognitive portion of the Alzheimer's Disease Assessment scale scores). Conclusions. While earlier literature promoted the use of zinc in AD patients, a recent study has contradicted this and implicated zinc in the aetiology of Alzheimer's disease. On the basis of the above results, it may be premature to single out zinc as a causal agent in AD.
dc.description.versionPublisher’s version
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7217
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectAlzheimer's diseaseen_ZA
dc.subjectZincen_ZA
dc.subjectBlood plateletsen_ZA
dc.titleZinc and platelet membrane microviscosity in Alzheimer's disease. The in vivo effect of zinc on platelet membranes and cognitionen_ZA
dc.typeArticle
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