Catastrophic intracerebral hemorrhage in a young infant with wilms tumor

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dc.contributor.authorVan Toorn R.
dc.contributor.authorWessels G.
dc.contributor.authorStefan C.
dc.date.accessioned2011-05-15T16:17:07Z
dc.date.available2011-05-15T16:17:07Z
dc.date.issued2007
dc.description.abstractWe present a 7-month-old male infant with stage I Wilms tumor who unexpectedly died from a catastrophic intracerebral hemorrhage, 4 months after completion of chemotherapy and complete surgical resection of the tumor. The precise etiology underlying the fatal event remains unclear as postmortem was refused, but we postulate spontaneous hemorrhage from an underlying cerebral vascular malformation as the most likely cause, which led to the child's unfortunate demise. Although extremely rare, cerebral vascular anomalies have previously been reported in children with Wilms tumor. The coexistence of the 2 uncommon disorders may be related to their congenital origin. Wilms tumor diagnosed in very young infants have clinical and morphologic attributes that do not pertain in older children and the risk of associated congenital anomalies is also much higher among those discovered in the first year of life. This raises the question whether routine magnetic resonance imaging should not be performed in infants less than a year with Wilms tumor, as part of the initial evaluation, to exclude cerebral metastases and underlying vascular malformations. © 2007 Lippincott Williams & Wilkins, Inc.
dc.description.versionArticle
dc.identifier.citationJournal of Pediatric Hematology/Oncology
dc.identifier.citation29
dc.identifier.citation5
dc.identifier.issn10774114
dc.identifier.other10.1097/MPH.0b013e3180587e7a
dc.identifier.urihttp://hdl.handle.net/10019.1/14080
dc.subjectdactinomycin
dc.subjectvincristine
dc.subjectanamnesis
dc.subjectarticle
dc.subjectaspiration biopsy
dc.subjectbrain hemorrhage
dc.subjectcancer combination chemotherapy
dc.subjectcancer staging
dc.subjectcancer surgery
dc.subjectcase report
dc.subjectcause of death
dc.subjectclinical examination
dc.subjectclinical feature
dc.subjectdiagnostic approach route
dc.subjectdiagnostic imaging
dc.subjectdiagnostic test
dc.subjectdisease course
dc.subjecthuman
dc.subjectinfant
dc.subjectkidney biopsy
dc.subjectkidney mass
dc.subjectmale
dc.subjectnephroblastoma
dc.subjectneuroimaging
dc.subjectpriority journal
dc.subjectCombined Modality Therapy
dc.subjectFatal Outcome
dc.subjectHumans
dc.subjectInfant
dc.subjectIntracranial Hemorrhages
dc.subjectKidney Neoplasms
dc.subjectMale
dc.subjectSensitivity and Specificity
dc.subjectTomography, X-Ray Computed
dc.subjectWilms Tumor
dc.titleCatastrophic intracerebral hemorrhage in a young infant with wilms tumor
dc.typeArticle
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