Mesothelial reaction to asbestos and other irritants after intraperitoneal injection
Date
1975
Authors
Engelbrecht, F. M.
Burger, B. F.
Journal Title
Journal ISSN
Volume Title
Publisher
Health and Medical Publishing Group (HMPG)
Abstract
Ten groups of rats were injected intraperitoneally with one of the following suspensions; standard reference crocidolite; acid treated crocidolite; crocidolite + iron oxide; crocidolite + silica; iron oxide; silica; long fiber crocidolite; short fiber crocidolite; long fiber glass and short fiber glass. Two rats from each group were killed at 45, 90, 150, 240 and 330 days respectively, and the pathology induced by the different suspensions was studied histologically at each time interval. No evidence in support of the chemical induction theory of mechanical irritation theory in the pathogenesis of peritoneal mesotheliomas could be found, although all the suspensions except iron oxide caused a reactive mesothelium.
Description
Article
The original publication is available from http://www.samj.org.za
Bibliography
The original publication is available from http://www.samj.org.za
Bibliography
Keywords
Rats as laboratory animals -- Experiments., Rats -- Effect of intraperitoneal drug administration on, Foreign body reaction in rats -- Diagnosis, Peritoneal mesotheliomas, Asbestos as a carcinogen
Citation
Engelbrecht, F.M. & Burger B.F. 1975, Mesothelial reaction to asbestos and other irritants after intraperitoneal injection, SA Medical Journal, 49(3),87-90, http://archive.samj.org.za/