Research Articles (Statistics and Actuarial Science)
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- ItemDoes money "buy" tolerance toward damage-causing wildlife?(Wiley, 2020-07-26) Kansky, Ruth; Kidd, Martin; Fischer, JoernThe Kavango-Zambezi Transfrontier Conservation Area supports large-scale migrations of wildlife that occur in a mixed agri-conservation landscape in five Southern African countries. Human–Wildlife Conflict is a key challenge and understanding the drivers of communities' willingness to coexist with wildlife is thus critical. Community based natural resource management (CBNRM) is a widely used economic approach to foster human-wildlife coexistence with the assumption that monetary benefits can “buy” tolerance by offsetting the disservices of living with wildlife. We tested this assumption and hypothesized that Namibians would be more tolerant towards wildlife than Zambians because they received higher monetary benefits from wildlife. We used the Wildlife Tolerance Model (WTM) as the framework to define tolerance and identify tolerance drivers. We found Namibians tolerance was higher for lion, elephant and hyena but not for kudu and baboon. After controlling for confounding variables of the WTM that could potentially explain differences in tolerance, contrary to expectation, the monetary benefits did not account for higher Namibian tolerance. Instead, only nonmonetary benefits explained the higher tolerance. We used crowding theory to explain this finding, proposing that CBNRM in Namibia and the monetary benefits from the program “crowd in” intrinsic motivation to appreciate and tolerate wildlife.
- ItemInvolvement of the spinal cord in primary mitochondrial disorders : a neuroimaging mimicker of inflammation and ischemia in children(American Journal of Neuroradiology, 2021-02) Alves, C. A. P. F.; Goldstein, A.; Teixeira, S. R.; Martin-Saavedra, J. S.; De Barcelos, I. P.; Fadda, G.; Caschera, L.; Kidd, M.; Gonçalves, F. G.; McCormick, E. M.; Falk, M. J.; Zolkipli-Cunningham, Z.; Vossough, A.; Zuccoli, G.Background and purpose: Little is known about imaging features of spinal cord lesions in mitochondrial disorders. The aim of this research was to assess the frequency, imaging features, and pathogenic variants causing primary mitochondrial disease in children with spinal cord lesions. Materials and methods: This retrospective analysis included patients seen at Children's Hospital of Philadelphia between 2000 and 2019 who had a confirmed diagnosis of a primary (genetic-based) mitochondrial disease and available MR imaging of the spine. The MR imaging included at least both sagittal and axial fast spin-echo T2-weighted images. Spine images were independently reviewed by 2 neuroradiologists. Location and imaging features of spinal cord lesions were correlated and tested using the Fisher exact test. Results: Of 119 children with primary mitochondrial disease in whom MR imaging was available, only 33 of 119 (28%) had available spine imaging for reanalysis. Nineteen of these 33 individuals (58%) had evidence of spinal cord lesions. Two main patterns of spinal cord lesions were identified: group A (12/19; 63%) had white ± gray matter involvement, and group B (7/19; 37%) had isolated gray matter involvement. Group A spinal cord lesions were similar to those seen in patients with neuromyelitis optica spectrum disorder, multiple sclerosis, anti-myelin oligodendrocyte glycoprotein-IgG antibody disease, and leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Group B patients had spinal cord findings similar to those that occur with ischemia and viral infections. Significant associations were seen between the pattern of lesions (group A versus group B) and the location of lesions in cervical versus thoracolumbar segments, respectively (P < .01). Conclusions: Spinal cord lesions are frequently observed in children with primary mitochondrial disease and may mimic more common causes such as demyelination and ischemia.
- ItemOn the convergence of gaussian belief propagation with nodes of arbitrary size(Journal of Machine Learning Research, 2019) Kamper, Francois; Steel, Sarel J.; Du Preez, Johan A.This paper is concerned with a multivariate extension of Gaussian message passing applied to pairwise Markov graphs (MGs). Gaussian message passing applied to pairwise MGs is often labeled Gaussian belief propagation (GaBP) and can be used to approximate the marginal of each variable contained in the pairwise MG. We propose a multivariate extension of GaBP (we label this GaBP-m) that can be used to estimate higher-dimensional marginals. Beyond the ability to estimate higher-dimensional marginals, GaBP-m exhibits better convergence behavior than GaBP, and can also provide more accurate univariate marginals. The theoretical results of this paper are based on an extension of the computation tree analysis conducted on univariate nodes to the multivariate case. The main contribution of this paper is the development of a convergence condition for GaBP-m that moves beyond the walk-summability of the precision matrix. Based on this convergence condition, we derived an upper bound for the number of iterations required for convergence of the GaBP-m algorithm. An upper bound on the dissimilarity between the approximate and exact marginal covariance matrices was established. We argue that GaBP-m is robust towards a certain change in variables, a property not shared by iterative solvers of linear systems, such as the conjugate gradient (CG) and preconditioned conjugate gradient (PCG) methods. The advantages of using GaBP-m over GaBP are also illustrated empirically.
- ItemLongitudinal population dynamics of staphylococcus aureus in the nasopharynx during the first year of life(Frontiers Media, 2019) Abdulgader, Shima M.; Robberts, Lourens; Ramjith, Jordache; Nduru, Polite M.; Dube, Felix; Lubbe, Sugnet, 1973-; Zar, Heather J.; Nicol, Mark P.Background: Staphylococcus aureus colonization is a risk factor for invasive disease. Few studies have used strain genotype data to study S. aureus acquisition and carriage patterns. We investigated S. aureus nasopharyngeal carriage in infants in an intensively sampled South African birth cohort. Methods: Nasopharyngeal swabs were collected at birth and fortnightly from 137 infants through their first year of life. S. aureus was characterized by spa-typing. The incidence of S. aureus acquisition, and median carriage duration for each genotype was determined. S. aureus carriage patterns were defined by combining the carrier index (proportion of samples testing positive for S. aureus) with genotype diversity measures. Persistent or prolonged carriage were defined by a carrier index ≥0.8 or ≥0.5, respectively. Risk factors for time to acquisition of S. aureus were determined. Results: Eighty eight percent (121/137) of infants acquired S. aureus at least once. The incidence of acquisition at the species and genotype level was 1.83 and 2.8 episodes per child-year, respectively. No children had persistent carriage (defined as carrier index of >0.8). At the species level 6% had prolonged carriage, while only 2% had prolonged carriage with the same genotype. Carrier index correlated with the absolute number of spa-CCs carried by each infant (r = 0.5; 95% CI 0.35–0.62). Time to first acquisition of S. aureus was shorter in children from households with ≥5 individuals (HR 1.06, 95% CI 1.07–1.43), with S. aureus carrier mothers (HR; 1.5, 95% CI 1.2–2.47), or with a positive tuberculin skin test during the first year of life (HR; 1.81, 95% CI 0.97–3.3). Conclusion: Using measures of genotype diversity, we showed that S. aureus NP carriage is highly dynamic in infants. Prolonged carriage with a single strain occurred rarely; persistent carriage was not observed. A correlation was observed between carrier index and genotype diversity.
- ItemBasic in-mouth attribute evaluation : a comparison of two panels(MDPI, 2018-12-21) Mihnea, Mihaela; Aleixandre-Tudo, Jose Luis; Kidd, Martin; Du Toit, WesselAstringency is often difficult to evaluate accurately in wine because of its complexity. This accuracy can improve through training sessions, but it can be time-consuming and expensive. A way to reduce these costs can be the use of wine experts, who are known to be reliable evaluators. Therefore, the aim of this work was to compare the sensory results and the panel performance obtained using trained panelists versus wine experts (winemakers). Judges evaluated twelve red wines for in-mouth basic perception (sweet, sour, bitter, astringent, and burning sensation) following the same tasting protocol and with the samples being presented in two different tasting modalities. Panels’ performance and relationship between the chemical composition and the sensory perception were investigated. Both panels showed similar consistency and repeatability, and they were able to accurately measure the astringency of the wines. However, the significant correlations between sensory scores and chemical composition varied with the panel and the tasting modality. From our results, we could see that winemakers tended to discriminate better between the samples when the differences were very small.