In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives

Date
2011
Authors
Evdokimov N.M.
Lamoral-Theys D.
Mathieu V.
Andolfi A.
Frolova L.V.
Pelly S.C.
Van Otterlo W.A.L.
Magedov I.V.
Kiss R.
Evidente A.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Description
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Keywords
1 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl benzoate, 1 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl pivalate, 1 hydroxy 4,5,7,12b tetrahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 2(3a1h) one, 1,2 dihydroxy 3a1,4,5,12b tetrahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(2h) one, 1,2,3 trihydroxy 2,3,5,12b tetrahydroxy1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(3a1h) one, 1,2,3,4 tetrahydroxy 3,3a,3a1,4,5,12b hexahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(2h) one, 2 (triisopropylsilyloxy) 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 ol, 2 (triisopropylsilyloxy)2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl acetate, 2 (triisopropylsilyloxy)2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl palmitate, 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl acetate, 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl benzoate, 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl palmitate, 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl stearate, 2 hydroxy 4h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(5h) one, 2,3a,4,5,7,12b hexahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate, 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl dibenzoate, 3,3a dihydroxy 7 oxo 2,3,3a,3a,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate, 3a hydroxy 7 oxo 2,3,3a,3a1,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,triyl triacetate, 7 oxo 2,3,3a1,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,triyl triacetate, 7 oxo 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate, 7 oxo 5,7 dihydro 4h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl acetate, 7 thioxo 2,3,3a,3a1,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,3a tetraol, 7 thioxo 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate, alkene, cytostatic agent, hydroxyl group, long chain fatty acid, lycorine, paclitaxel, unclassified drug, unindexed drug, antineoplastic activity, apoptosis, article, cancer inhibition, controlled study, derivatization, dihydroxylation, drug structure, drug synthesis, glioblastoma, human, in vitro study, lung non small cell cancer, melanoma, nonhuman, solid tumor, structure activity relation, tumor cell line, Amaryllidaceae
Citation
Bioorganic and Medicinal Chemistry
19
23
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