Social anxiety disorder and generalized anxiety disorder: Serotonergic and dopaminergic neurocircuitry
Date
2002
Authors
Stein D.J.
Westenberg H.G.M.
Liebowitz M.R.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Awareness that an amygdala-based fear circuit plays a crucial role in mediating fear conditioning as well as anxiety symptoms is growing. The efficacy of selective serotonin reuptake inhibitors in certain anxiety disorders has been argued to reflect their ability to modulate this circuit. Whether additional neurocircuits play a differentiating role in specific anxiety disorders, such as social anxiety disorder and generalized anxiety disorder (GAD), is an ongoing subject of investigation. A review of the literature suggests that in social anxiety disorder, dopaminergically mediated striatal circuits may also be important, while in GAD, there may be abnormalities of prefrontal areas. Future work will undoubtedly clarify how genetic and environmental factors interact to fashion the neurocircuitry that mediates anxiety symptoms.
Description
Keywords
benzodiazepine, benzodiazepine receptor, buspirone, dopamine, dopamine 2 receptor stimulating agent, dopamine receptor blocking agent, fenfluramine, fluvoxamine, gabapentin, neuropeptide, oxytocin, paroxetine, serotonin, serotonin 1A agonist, serotonin uptake inhibitor, amygdaloid nucleus, anxiety, anxiety neurosis, basal ganglion, clinical trial, conditioning, conference paper, dopaminergic system, drug efficacy, fear, GABAergic system, genetic polymorphism, human, nerve cell network, nonhuman, noradrenergic system, prefrontal cortex, priority journal, provocation test, psychopharmacology, serotoninergic system, social phobia, Amygdala, Anxiety Disorders, Corpus Striatum, Dopamine, Humans, Models, Neurological, Neural Pathways, Phobic Disorders, Prefrontal Cortex, Serotonin, Serotonin Uptake Inhibitors, Synaptic Transmission
Citation
Journal of Clinical Psychiatry
63
SUPPL. 6
63
SUPPL. 6